Norbormide
Encyclopedia
Norbormide is a toxic compound used as a rodenticide. It has several mechanisms of action, acting as a vasoconstrictor and calcium channel blocker
, but is selectively toxic to rat
s and has relatively low toxicity to other species, due to a species specific action of opening the permeability transition pores in rat mitochondria.
Calcium channel blocker
A calcium channel blocker is a chemical that disrupts the movement of calcium through calcium channels.CCB drugs devised to target neurons are used as antiepileptics. However, the most widespread clinical usage of calcium channel blockers is to decrease blood pressure in patients with...
, but is selectively toxic to rat
Rat
Rats are various medium-sized, long-tailed rodents of the superfamily Muroidea. "True rats" are members of the genus Rattus, the most important of which to humans are the black rat, Rattus rattus, and the brown rat, Rattus norvegicus...
s and has relatively low toxicity to other species, due to a species specific action of opening the permeability transition pores in rat mitochondria.