Nortilidine
Encyclopedia
Nortilidine is the active metabolite
of the drug Tilidine
. It is formed from Tilidine
by demethylation
in the liver
. The racemate has opioid analgesic effects roughly equivalent in potency to that of morphine but virtually all of the activity resides in the (1R,2S) isomer.
Active metabolite
- Prodrugs :Sometimes drugs are formulated deliberately so they will break down inside the body to form the active drug, these are called prodrugs. The reason for this may be because the drug is more stable during manufacture and storage as the prodrug form, or because the prodrug is better...
of the drug Tilidine
Tilidine
Tilidine , or tilidate is a synthetic opioid analgesic, used mainly in Germany, Switzerland and Belgium for treatment of moderate to severe pain, both acute and chronic.-Pharmacology:...
. It is formed from Tilidine
Tilidine
Tilidine , or tilidate is a synthetic opioid analgesic, used mainly in Germany, Switzerland and Belgium for treatment of moderate to severe pain, both acute and chronic.-Pharmacology:...
by demethylation
Demethylation
Demethylation is the chemical process resulting in the removal a of methyl group from a molecule.A common way of demethylation is the replacement of a methyl group by a hydrogen atom, resulting in a net loss of one carbon and two hydrogen atoms....
in the liver
Liver
The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion...
. The racemate has opioid analgesic effects roughly equivalent in potency to that of morphine but virtually all of the activity resides in the (1R,2S) isomer.