Origin recognition complex subunit 1 is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the ORC1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Function

The origin recognition complex

Origin Recognition Complex

ORC or Origin Recognition Complex is a multi-subunit DNA binding complex that binds in all eukaryotes in an ATP-dependent manner to origins of replication....

 (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication

DNA replication

DNA replication is a biological process that occurs in all living organisms and copies their DNA; it is the basis for biological inheritance. The process starts with one double-stranded DNA molecule and produces two identical copies of the molecule...

 in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of the pre-replication complex

Pre-replication complex

A pre-replication complex is a protein complex that forms at the origin of replication during the initiation step of DNA replication. Formation of the pre-RC is required for DNA replication to occur. Complete and faithful replication of the genome ensures that each daughter cell will carry the...

, which includes additional initiation factors such as Cdc6

Cdc6

Cdc6, or Cell Division Cycle 6, is a protein in eukaryotic cells that is studied in the budding yeast Saccharomyces cerevisiae. It is an essential regulator of DNA replication and plays important roles in the activation and maintenance of the checkpoint mechanisms in the cell cycle that coordinate...

 and Mcm

MCM

-Science and technology:* Thousand circular mils or kcmil, the wire gauge is equivalent cross sectional area * Million cubic metre, the unit of volume...

 proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle

Cell cycle

The cell cycle, or cell-division cycle, is the series of events that takes place in a cell leading to its division and duplication . In cells without a nucleus , the cell cycle occurs via a process termed binary fission...

, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis

Proteolysis

Proteolysis is the directed degradation of proteins by cellular enzymes called proteases or by intramolecular digestion.-Purposes:Proteolysis is used by the cell for several purposes...

 after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis

Mitosis

Mitosis is the process by which a eukaryotic cell separates the chromosomes in its cell nucleus into two identical sets, in two separate nuclei. It is generally followed immediately by cytokinesis, which divides the nuclei, cytoplasm, organelles and cell membrane into two cells containing roughly...

. It is also reported to interact with MYST histone acetyltransferase 2

MYST2

Histone acetyltransferase MYST2 is an enzyme that in humans is encoded by the MYST2 gene.-Interactions:MYST2 has been shown to interact with Androgen receptor, ORC1L and Vimentin.-Further reading:...

 (MYST2/HBO1), a protein involved in control of transcription silencing.

Interactions

ORC1L has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with ORC2L

ORC2L

Origin recognition complex subunit 2 is a protein that in humans is encoded by the ORC2L gene.-Interactions:ORC2L has been shown to interact with ORC1L, Replication protein A1, ORC4L, ORC5L, ORC3L, MCM4, CDC6, MCM5, MCM6, MCM7, MCM10, DBF4, MCM2 and ORC6L.-Further reading:...

, ORC4L

ORC4L

Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4L gene.-Interactions:ORC4L has been shown to interact with ORC1L, MCM6, ORC2L, ORC5L, ORC3L, MCM2, MCM4, MCM3 and ORC6L.-Further reading:...

, ORC5L

ORC5L

Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5L gene.-Interactions:ORC5L has been shown to interact with ORC1L, ORC2L, MCM7, ORC4L, ORC3L, MCM2, MCM4 and MCM3.-Further reading:...

, MCM4

MCM4

DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.-Interactions:MCM4 has been shown to interact with ORC1L, ORC2L, Replication protein A1, ORC4L, ORC5L, ORC3L, MCM6, MCM7, MCM2, Cell division cycle 7-related protein kinase and ORC6L.-Further reading:...

, MYST2

MYST2

Histone acetyltransferase MYST2 is an enzyme that in humans is encoded by the MYST2 gene.-Interactions:MYST2 has been shown to interact with Androgen receptor, ORC1L and Vimentin.-Further reading:...

, CDC6

CDC6

Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.-Interactions:CDC6 has been shown to interact with ORC1L, ORC2L, Cyclin A2, PPP2R3B, MCM3, PPP2R3A, MCM7 and PSKH1.-Further reading:...

, Cyclin-dependent kinase 2

Cyclin-dependent kinase 2

Cyclin-dependent kinase 2 also known as cell division protein kinase 2 is an enzyme that in humans is encoded by the CDK2 gene.-Function:...

, MCM6

MCM6

DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins that are essential for the initiation of eukaryotic genome replication....

, SKP2

SKP2

S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the SKP2 gene.- Function :This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box domain...

, MCM7

MCM7

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.-Interactions:MCM7 has been shown to interact with Replication protein A1, ORC3L, Retinoblastoma protein, MCM5, MCM6, ORC1L, ORC2L, ORC5L, MCM4, MCM3, CDC6, MNAT1, DBF4, MCM2, UBE3A, CDC45-related protein...

, MCM2

MCM2

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.-Interactions:MCM2 has been shown to interact with Replication protein A1, AKAP8, MCM5, MCM6, MCM7, ORC1L, ORC2L, ORC4L, ORC5L, MCM4, MCM3 and Cell division cycle 7-related protein kinase.-Further reading:...

, CDC45-related protein

CDC45-related protein

CDC45 is a protein that in humans is encoded by the CDC45L gene.-Interactions:CDC45-related protein has been shown to interact with ORC1L, MCM6, MCM7, MCM3 and ORC6L.-Further reading:...

 and Cell division cycle 7-related protein kinase

Cell division cycle 7-related protein kinase

Cell division cycle 7-related protein kinase is an enzyme that in humans is encoded by the CDC7 gene.- General Information About CDC7 :Cell division cycle 7 is a gene that codes for the protein Cdc7 kinase...

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