The Ohio Valley Athletic Conference is a high school sports league in parts of southeastern Ohio and northern West Virginia. The "OVAC" is the largest conference of its kind in the United States. Schools in the upper Ohio Valley supply over 12,000 athletes in various competitive athletic areas. The conference was organized in 1943.

• Beallsville
  Beallsville High School
  Beallsville High School is a public high school in Beallsville, Ohio. It is one of three high schools in the Switzerland of Ohio Local School District. Their nickname is the Blue Devils...
  
  , Beallsville, OH
• Bishop Donahue
  Bishop Donahue Memorial High School
  Bishop Donahue Memorial High School is a private, Roman Catholic high school in McMechen, West Virginia. It is part of the Roman Catholic Diocese of Wheeling-Charleston. It was named after Bishop Patrick James Donahue , who served as the third Bishop of the Diocese of Wheeling from 1894 until his...
  
  , McMechen, WV
• Conotton Valley
  Conotton Valley High School
  Conotton Valley High School is a public high school in Bowerston, Ohio, United States. It is the only high school in the Conotton Valley Union Local School District. Their nickname is the Rockets. The Rockets are members of the Ohio Valley Athletic Conference and the Inter Valley...
  
  , Bowerston, OH
• East Richland Christian School, St.