Oportuzumab monatox
Encyclopedia
Oportuzumab monatox is an antineoplastic. Chemically, oportuzumab it is a single chain variable fragment
of a monoclonal antibody which binds to epithelial cell adhesion molecule
(EpCAM, the tumor-associated calcium signal transducer 1). Oportuzumab is fused with Pseudomonas aeruginosa
exotoxin A (which is reflected by the monatox in the drug's name).
Single chain variable fragment
A single-chain variable fragment is a fusion protein of the variable regions of the heavy and light chains of immunoglobulins, connected with a short linker peptide of ten to about 25 amino acids...
of a monoclonal antibody which binds to epithelial cell adhesion molecule
Epithelial cell adhesion molecule
Epithelial cell adhesion molecule is a protein that in humans is encoded by the EPCAM gene. EpCAM has also been designated as TACSTD1 and CD326 ....
(EpCAM, the tumor-associated calcium signal transducer 1). Oportuzumab is fused with Pseudomonas aeruginosa
Pseudomonas aeruginosa
Pseudomonas aeruginosa is a common bacterium that can cause disease in animals, including humans. It is found in soil, water, skin flora, and most man-made environments throughout the world. It thrives not only in normal atmospheres, but also in hypoxic atmospheres, and has, thus, colonized many...
exotoxin A (which is reflected by the monatox in the drug's name).