Outer membrane efflux protein family

Protein family

A protein family is a group of evolutionarily-related proteins, and is often nearly synonymous with gene family. The term protein family should not be confused with family as it is used in taxonomy....

 form trimeric
channels that allow export of a variety of substrates in Gram
negative bacteria. Each member of this family is composed of
two repeats. The trimeric channel is composed of a 12 stranded
all beta sheet barrel that spans the outer membrane, and a long
all helical barrel that spans the periplasm.

Examples include the Escherichia coli

Escherichia coli

Escherichia coli is a Gram-negative, rod-shaped bacterium that is commonly found in the lower intestine of warm-blooded organisms . Most E. coli strains are harmless, but some serotypes can cause serious food poisoning in humans, and are occasionally responsible for product recalls...

TolC outer membrane protein, which is required for proper expression of outer membrane protein genes; the Rhizobium nodulation protein; and the Pseudomonas FusA protein, which is involved in resistance to fusaric acid

Fusaric acid

Fusaric acid is a picolinic acid derivative. It is typically isolated from various Fusarium species, and has been proposed for a various therapeutic applications. However, it is primarily used as a research tool....

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Subfamilies

• Type I secretion outer membrane protein, TolC 
• RND efflux system, outer membrane lipoprotein, NodT