PEX12
Encyclopedia
Peroxisome assembly protein 12 is a protein
that in humans is encoded by the PEX12 gene
.
with PEX10
, PEX5
and PEX19
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the PEX12 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
The peroxisome biogenesis disorders (PBDs; MIM 601539) are a group of genetically heterogeneous diseases that are usually lethal in early infancy. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. This cellular phenotype is shared by yeast 'pex' mutants, and human orthologs of yeast PEX genes defective in some PBD complementation groups (CGs).[supplied by OMIM]Interactions
PEX12 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with PEX10
PEX10
Peroxisome biogenesis factor 10 is a protein that in humans is encoded by the PEX10 gene.- Function :Peroxisome biogenesis factor 10 os involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane...
, PEX5
PEX5
Peroxisomal targeting signal 1 receptor is a protein that in humans is encoded by the PEX5 gene.-Interactions:PEX5 has been shown to interact with PEX12, PEX13 and PEX14.-External Links:* *...
and PEX19
PEX19
Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene.-Interactions:PEX19 has been shown to interact with PEX10, PEX12, PEX13, ABCD3, ABCD1, PEX3, ABCD2, PEX11B and PEX16.-External Links:* *...
.