PKN3 is a protein kinase C

Protein kinase C

Protein kinase C also known as PKC is a family of enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. PKC enzymes in turn are activated by signals such as increases in...

-related molecule and thought to be an effector

Effector

Effector may refer to:*An actuator, in robotics*Effector , a music album by the Experimental Techno group Download*Effector cell, a type of lymphocyte in immunology...

 mediating malignant cell growth downstream of activated phosphoinositide 3-kinase (PI3K). It is thought that chronic activation of the phosphoinositide 3-kinase (PI3K)/PTEN

PTEN (gene)

Phosphatase and tensin homolog is a protein that, in humans, is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers....

 signal transduction pathway contributes to metastatic cell growth and that PKN3 may mediate that growth.1

PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 may represent a target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.

Interactions

PKN3 (gene) has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with ARHGAP26

ARHGAP26

Rho GTPase activating protein 26 also known as GTPase Regulator Associated with Focal Adhesion Kinase is a protein which in humans is encoded by the ARHGAP26 gene.-Function:...

.

Further reading