POLH
Overview
 
Polymerase eta, also known as POLH, is a protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 which in humans is encoded by the POLH gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.
This gene encodes a member of the Y family of specialized DNA polymerase
DNA polymerase
A DNA polymerase is an enzyme that helps catalyze in the polymerization of deoxyribonucleotides into a DNA strand. DNA polymerases are best known for their feedback role in DNA replication, in which the polymerase "reads" an intact DNA strand as a template and uses it to synthesize the new strand....

s. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage.
Quotations

[When the Allied forces fire on him] Why are you always messing with me. It's got to be a joke!

[Convincing Shimizu not to kill himself] We can die here, or we can continue fighting. Which would better serve the emperor?

[Letter to his wife] We soldiers dig. We dig all day. This is the hole that we will fight and die in. Am I digging my own grave?

[About Nishi's romancing skills] There are rumors about his womanizing...But there are no women left to woo.

[In response to a soldier saying death is honorable] Kashiwara died of honorable dysentery.

There is no use for a dead soldier.

Damn this island! The Americans can have it.

Do what is right because it is right.

If you want my honest opinion, General, the best thing to do would be to sink this island to the bottom of the sea.

I'm tired of sharing this cave with all of you, I'm a one-man show from now on.

 
x
OK