Panos G. Georgopoulos, Ph.D. is a scientist

Scientist

A scientist in a broad sense is one engaging in a systematic activity to acquire knowledge. In a more restricted sense, a scientist is an individual who uses the scientific method. The person may be an expert in one or more areas of science. This article focuses on the more restricted use of the word...

 working in the field of Environmental Health

Environmental health

Environmental health is the branch of public health that is concerned with all aspects of the natural and built environment that may affect human health...

 and specializing in Mathematical Modeling of Environmental and Biological Systems. He is the architect or the MOdeling ENvironment for Total Risk studies (MENTOR)
and the DOse Response Information and ANalysis system (DORIAN) , both under continuing development at the Computational Chemodynamics Laboratory of the Environmental and Occupational Health Sciences Institute (EOHSI). Funding for his work has been provided by the United States Environmental Protection Agency

United States Environmental Protection Agency

The U.S. Environmental Protection Agency is an agency of the federal government of the United States charged with protecting human health and the environment, by writing and enforcing regulations based on laws passed by Congress...

, United States Department of Energy

United States Department of Energy

The United States Department of Energy is a Cabinet-level department of the United States government concerned with the United States' policies regarding energy and safety in handling nuclear material...

, National Institutes of Health

National Institutes of Health

The National Institutes of Health are an agency of the United States Department of Health and Human Services and are the primary agency of the United States government responsible for biomedical and health-related research. Its science and engineering counterpart is the National Science Foundation...

, Centers for Disease Control, New Jersey Department of Environmental Protection

New Jersey Department of Environmental Protection

The New Jersey Department of Environmental Protection is a government agency in the U.S. state of New Jersey that is responsible for managing the state's natural resources and addressing issues related to pollution...

, New Jersey Department of Health and Senior Services

New Jersey Department of Health and Senior Services

The New Jersey Department of Health and Senior Services is a governmental agency of the U.S. state of New Jersey.New Jersey's State Board of Health was established in 1877. Its administrative functions were vested in the Department of Health, which was created in 1947. In 1996, the latter was...

, American Chemistry Council

American Chemistry Council

The American Chemistry Council , formerly known as the Manufacturing Chemists' Association and then as the Chemical Manufacturers' Association , is an industry trade association for American chemical companies, based in Washington, D.C.-Activities:The mission of the American Chemistry Council is...

, and other public and private agencies.

Biography

Panos G. Georgopoulos is Professor of Environmental and Occupational Medicine at the University of Medicine and Dentistry of New Jersey

University of Medicine and Dentistry of New Jersey

The University of Medicine and Dentistry of New Jersey is the state-run health sciences institution of New Jersey, United States. It has eight distinct academic units...

 - Robert Wood Johnson Medical School

Robert Wood Johnson Medical School

Robert Wood Johnson Medical School is a public medical school located in Piscataway and New Brunswick, New Jersey, and one of the eight schools of the University of Medicine and Dentistry of New Jersey . In cooperation with Robert Wood Johnson University Hospital, the medical school’s principal...

. He is also a member of the Graduate Faculties of Chemical and Biochemical Engineering, Biomedical Engineering, and of Environmental Sciences at Rutgers University

Rutgers University

Rutgers, The State University of New Jersey , is the largest institution for higher education in New Jersey, United States. It was originally chartered as Queen's College in 1766. It is the eighth-oldest college in the United States and one of the nine Colonial colleges founded before the American...

, and a member of the Environmental and Occupational Health Sciences Institute (EOHSI), which is a joint institute of UMDNJ-RWJMS and Rutgers. Georgopoulos received his M.S. and Ph.D. Degrees in Chemical Engineering from the California Institute of Technology

California Institute of Technology

The California Institute of Technology is a private research university located in Pasadena, California, United States. Caltech has six academic divisions with strong emphases on science and engineering...

 (Caltech) and his Dipl. Ing. Degree from the National Technical University of Athens

National Technical University of Athens

The National Technical University of Athens , sometimes simply known as Athens Polytechnic, is among the oldest and most prestigious higher education institutions of Greece....

. At EOHSI he established and directs the Computational Chemodynamics Laboratory (CCL), a state-of-the-art facility for informatics and modeling of complex environmental and biological systems. Furthermore, he directs the State-funded Ozone Research Center and co-directs the Center for Exposure and Risk Modeling (CERM) at EOHSI. He is Co-Director of the Environmental Bioinformatics and Computational Toxicology Center (ebCTC), a research consortium of UMDNJ-RWJMS

University of Medicine and Dentistry of New Jersey

The University of Medicine and Dentistry of New Jersey is the state-run health sciences institution of New Jersey, United States. It has eight distinct academic units...

, Princeton University

Princeton University

Princeton University is a private research university located in Princeton, New Jersey, United States. The school is one of the eight universities of the Ivy League, and is one of the nine Colonial Colleges founded before the American Revolution....

, Rutgers University

Rutgers University

Rutgers, The State University of New Jersey , is the largest institution for higher education in New Jersey, United States. It was originally chartered as Queen's College in 1766. It is the eighth-oldest college in the United States and one of the nine Colonial colleges founded before the American...

 and USFDA's Center for Toxicoinformatics. He is also Co-Director of the Bioinformatics, Biostatistics and Computational Toxicology Core for the NIEHS Center for Environmental Exposures and Disease (CEED) at EOHSI. He served as Director of the USDOE-funded Center of Expertise in Exposure Assessment of the Consortium for Risk Evaluation with Stakeholder Participation (CRESP).

Georgopoulos has participated in both research and teaching in the graduate programs of Rutgers and UMDNJ-RWJMS

Robert Wood Johnson Medical School

Robert Wood Johnson Medical School is a public medical school located in Piscataway and New Brunswick, New Jersey, and one of the eight schools of the University of Medicine and Dentistry of New Jersey . In cooperation with Robert Wood Johnson University Hospital, the medical school’s principal...

 and has developed innovative course materials in modeling and informatics related to environmental health applications. He has been the primary doctoral thesis advisor to 18 students, with 11 Ph.D. degrees awarded since 1997, and has been mentor to 24 post-doctoral fellows. His research interests involve the development and application of novel mathematical and computational methods for diagnostic and mechanistic studies of multipathway physicochemical processes taking place in interacting environmental and biological systems. The aim of this research is to improve the understanding and quantification of human exposure and biological mechanism-based dosimetry and risk for environmental toxics; this is being accomplished through the ongoing development of a consistent mechanistic multiscale modular computational framework for source-to-dose-to-effect modeling of toxicant dynamics. Outcomes of this research include integrative computational models of toxicokinetic and toxicodynamic processes at the cellular, tissue and whole body levels.

Georgopoulos has lectured as an invited speaker at universities, including the Harvard School of Public Health

Harvard School of Public Health

The Harvard School of Public Health is one of the professional graduate schools of Harvard University, located in the Longwood Area of the Boston, Massachusetts neighborhood of Mission Hill, which is next to Harvard Medical School. HSPH is considered a significant school focusing on health in the...

, Johns Hopkins University

Johns Hopkins University

The Johns Hopkins University, commonly referred to as Johns Hopkins, JHU, or simply Hopkins, is a private research university based in Baltimore, Maryland, United States...

, Stanford University

Stanford University

The Leland Stanford Junior University, commonly referred to as Stanford University or Stanford, is a private research university on an campus located near Palo Alto, California. It is situated in the northwestern Santa Clara Valley on the San Francisco Peninsula, approximately northwest of San...

, Illinois Institute of Technology

Illinois Institute of Technology

Illinois Institute of Technology, commonly called Illinois Tech or IIT, is a private Ph.D.-granting university located in Chicago, Illinois, with programs in engineering, science, psychology, architecture, business, communications, industrial technology, information technology, design, and law...

, University of Minnesota

University of Minnesota

The University of Minnesota, Twin Cities is a public research university located in Minneapolis and St. Paul, Minnesota, United States. It is the oldest and largest part of the University of Minnesota system and has the fourth-largest main campus student body in the United States, with 52,557...

, and others. He has published more than 125 peer-reviewed articles and chapters in scientific journals, books and proceedings, and has authored or co-authored several State and Federal Government Documents and numerous technical reports. He has received awards and honors, including the DuPont

DuPont

E. I. du Pont de Nemours and Company , commonly referred to as DuPont, is an American chemical company that was founded in July 1802 as a gunpowder mill by Eleuthère Irénée du Pont. DuPont was the world's third largest chemical company based on market capitalization and ninth based on revenue in 2009...

 Education and Research Award, for his work on environmental pollution and health. He served on editorial boards of scientific journals and currently serves as member of various national and international scientific and technical committees on environmental issues.

Georgopoulos works in close association with Paul J. Lioy

Paul J. Lioy

Paul J. Lioy, Ph. D. is an American working in the field of Environmental Health and specializing in Exposure Science. He is one of the world’s leading experts in personal exposure to toxins....

, Director of the Exposure Science Division of EOHSI.

Education

• 1986 - Ph.D., Chemical Engineering, California Institute of Technology, Pasadena, California, U.S.A.
• 1982 - M.S., Chemical Engineering, California Institute of Technology, Pasadena, California, U.S.A.
• 1980 - Dipl. Ing., Chemical Engineering, National Technical University, Athens, Greece

Mathematical Modeling of Environmental and Biological Systems and their Interactions - Computational Chemodynamics and Toxicodynamics

• Multimedia transport, fate and uptake of environmental pollutants; photochemical smog; air toxics; persistent organics; heavy metals
• Physiologically-based toxicokinetics and pharmacokinetics; inhalation, ingestion and dermal absorption dosimetry
• Mechanistic toxicodynamics and pharmacodynamics
• Computational systems toxicology and toxicogenomics
• Multiscale biological modeling (from molecule to cell to tissue to organism to population) for toxicity and environmental health assessment

Environmental and Human Exposure Information Systems Methods

• Multidimensional/spatiotemporal data mining and diagnostic analysis via Geographic Information and Database Management Systems
• Multiroute/multipathway modeling of human exposure to toxics
• Enviroinformatics, cheminformatics, and bioinformatics

Risk and Uncertainty Analysis Methods

• Uncertainty characterization, analysis and reduction methods for environmental and occupational health risk assessment

Current Academic Appointments

• 2010–present: Co-Director, Environmental Bioinformatics and Computational Toxicology Center – a UMDNJ-RWJMS - Rutgers - Princeton - USFDA Research Consortium
• 2009–present: Associate Member, Cancer Institute of New Jersey, UMDNJ - Robert Wood Johnson Medical School
• 2007–present: Co-Director, Bioinformatics, Biostatistics and Computational Toxicology Core, NIEHS Center for Environmental Exposures and Disease at EOHSI
• 2004–present: Professor, Department of Environmental and Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ
• 2002–present: Member, Graduate Faculty, Department of Biomedical Engineering, Rutgers University
• 2000–present: Co-Director, Center for Exposure and Risk Modeling (CERM), Environmental and Occupational Health Sciences Institute, Piscataway, NJ
• 1994–present: Director, Ozone Research Center, Environmental and Occupational Health Sciences Institute, Piscataway, NJ
• 1992–present: Director, Computational Chemodynamics Laboratory, Environmental and Occupational Health Sciences Institute, Piscataway, NJ
• 1991–present: Member, Graduate Faculty, Department of Environmental Sciences, Rutgers University
• 1990–present: Member, Graduate Faculty, Department of Chemical and Biochemical Engineering, Rutgers University
• 1989–present: Member, Environmental and Occupational Health Sciences Institute, Piscataway, NJ

Selected Honors and Awards

• International Society for Environmental Epidemiology (ISEE) Citation of Appreciation (1999) for Leadership, Organization, and Exceptional Effort as Co-Chair of the Organizing Committee for the 1999 Conference
• International Society of Exposure Analysis (ISEA) Certificate in Appreciation of Service (1999) as Technical Program Chair of the 1999 Annual Conference
• U.S. EPA Certificate of Appreciation (1999) (for Contributions to the Development of Models-3)
• The DuPont Educational Award (1996)
• The PSE&G Educational Grant (1996)
• The DuPont Educational Award (1995)
• Society of Toxicology, Best Presentation in Risk Assessment Award (1994)
• The Dodecanesian Service Award (1992)

Editorial Positions

• 2001-2004: Member of Editorial Board, Stochastic Environmental Research and Risk Assessment
• 1999: Guest Co-Editor, Epidemiology (Supplement) (vol. 10, July 1999)
• 1995: Guest Co-Editor, Environmental Health Perspectives (vol. 103, March 1995, Supplement 2): Environmental Epidemiology, Health Effects of Ozone and Perinatal Exposure to Dioxins
• 1995-2001: Associate Editor, Journal of the Air and Waste Management Association

Georgopoulos also served as a reviewer for, among others, the following journals: Atmospheric Environment; Water, Air, and Soil Pollution; Environmental Health Perspectives

Environmental Health Perspectives

Environmental Health Perspectives is a peer-reviewed open-access medical journal published monthly by the National Institute of Environmental Health Sciences. According to the Journal Citation Reports, the journal has a 2009 impact factor of 6.191....

; Environmental Research; Environmental Science and Technology; Environmental Engineering Science; Journal of Exposure Science and Environmental Epidemiology; Journal of the Air and Waste Management Association; Journal of Computational Chemistry

Journal of Computational Chemistry

The Journal of Computational Chemistry is a peer-reviewed scientific journal published since 1980 by John Wiley & Sons. It covers research, contemporary developments in theory and methodology, and applications in all areas of computational chemistry, including ab initio quantum chemistry methods...

; Journal of Physical Chemistry

Journal of Physical Chemistry A

The Journal of Physical Chemistry A is a scientific journal which reports research on the chemistry of molecules - including their dynamics, spectroscopy, kinetics, structure, bonding, and quantum chemistry...

; Journal of Hazardous Materials; and Science of the Total Environment.

Service on National and International Grant Review Panels, Study Sections, and Committees

• 2010-2011: Member, Virtual Physiological Human (VPH) International Expert Group
• 2010-2011: Member, FIFRA Scientific Advisory Panel (FIFRA SAP) on scientific issues associated with Chlorpyrifos
• 2010: Member, USEPA Grant Review Panel, Computational Toxicology: Biologically-Based Multiscale Modeling

• 2010: Member, USEPA Exposure Factors Handbook (EFH) Peer Review Committee
• 2010: Member, External Scientific Advisory Panel, EU TAGS Project
• 2009: Member, USEPA Review Panel for Indoor Air Formaldehyde Modeling
• 2009: Member, Joint USEPA-European Union Science Panel for Virtual Tissues
• 2008: Member, USEPA Review Panel for Perchlorate Pharmacokinetics Modeling
• 2008: Member, NIH Review Panel, Instrumentation and Systems Development
• 2007: Member, USEPA Review Panel for Computational Toxicology STAR Grants
• 2007: Member, USEPA Child Specific Exposure Factors Handbook (CSEFH) Peer Review Committee
• 2006: Member, NIH Grant Review Panel: Arthritis, Connective Tissue and Skin Study Section (ACTS)
• 2005-2006: Member of USEPA's Science Advisory Board (SAB) Regulatory Environmental Modeling (REM) Guidance Review Panel
• 2003-2004: Reviewer, Cancer Institute of New Jersey Exploratory Research Grants
• 2001-2002: Member, Air Quality Modeling Subcommittee (AQMS) of the Advisory Council on Clean Air Compliance Analysis (for USEPA's Study of the Costs and Benefits of the Clean Air Act, 2000–2020)
• 2001-2002: Member, Environmental Modeling Subcommittee, National Air Toxics Assessment (NATA) Panel of EPA’s Scientific Advisory Board
• 2001–present: Reviewer, American Chemical Society Research Grants Program
• 2000–present: Reviewer, National Aeronautics and Space Administration (NASA) Life Sciences Division Research Program
• 2000-2007: Reviewer, USEPA Office of Prevention, Pesticides and Toxics Research Program
• 1999-2001: Member, Chemical Manufacturers Association Exposure Assessment Research Program Advisory Workgroup
• 1999–present: Reviewer, National Science Foundation Computational Mathematics (for Environmental Applications) Grant Program
• 1998-2001: Member, US Environmental Protection Agency Attainment Demonstration Guidance Review Workgroup
• 1994–present: Chemistry and Modeling Committee Member, North American Research Strategy for Tropospheric Ozone (NARSTO)
• 1994-1996: Member, Coordinating Committee of the NARSTO-Northeast Project
• 1992-1993: Working Group Member, USEPA Reassessment of Dioxin Project
• 1991-1992: Grant Review Panel Member, US Department of Energy Atmospheric Chemistry Program
• 1990-1994: National Modeling Committee Member, Regional Oxidant Modeling for Northeast Transport (ROMNET) Project

Service On Graduate School Committees

• 2001–present: Member, Steering Committee, Informatics Institute of UMDNJ
• 2001–present: Member, EOHSI Center for International Health Committee
• 2000-2002: Member, EOHSI Subcommittee on Future Research Directions
• 2000-2002: Member, EOHSI Membership Renewal and Criteria Committee
• 1995-1997: Member, Committee for the Development of a Graduate Program in Environmental Engineering at Rutgers University
• 1994-1995: Member, Interdisciplinary Campus-wide Environmental Science and Engineering Curriculum Assessment Committee
• 1993-1994: Member, Cook College (Rutgers University) Environmental Vision Planning Committee
• 1991-1993: Member, College of Engineering (Rutgers University) Graduate Recruitment Committee

Service to the Community

• 2010–present: Member, Executive Committee, Modern Greek Studies Program, Rutgers University
• 2010–present: President, Agios Gerasimos Cephalonian Association of NJ
• 2004-2007: Member, Board of Trustees, St George Greek Orthodox Church of Piscataway, New Jersey
• 2003–present: Director, St George Greek School, Piscataway, NJ
• 2003–present: Member, Central New Jersey AHEPA Educational Awards Committee
• 1997–present: Technical Advisory Board Member, EnviroComp Institute (www.envirocomp.org)
• 1993–present: Chairman of the Board of Trustees, Elytis Chair Fund at Rutgers University
• 1986–present: Technical/Scientific Advisor or Consultant: California Air Resources Board, U.S. Environmental Protection Agency, American Petroleum Institute, American Chemistry Council, New York City Law Department, Veterans Health Administration, etc.
• 1990-1999: Modeling Committee Member, Northeast States for Coordinated Air Use and Management (NESCAUM)
• 1997-1998: Faculty Advisor, Hellenic Premedical Association at Rutgers University
• 1993-1997: Faculty Advisor, Hellenic Cultural Association at Rutgers University
• 1990-1997: Modeling Coordinator (Chair), Philadelphia Consolidated Metropolitan Statistical Area Ozone Attainment State Implementation Plan Preparation
• 1990-1997: Modeling Committee Member, New York Metropolitan Statistical Area Ozone Attainment State Implementation Plan Preparation
• 1992-1996: Substitute Member, Clean Air Council of New Jersey
• 1991-1993: Technical Advisory Committee Member, Greenpoint/Williamsburg Environmental Benefits Program
• 1989-1991: Technical Committee Member, Project: Clean Air (for the State of New Jersey and the Delaware Valley Area)

Peer Reviewed Journal Articles (selected from the past 10 years)

1. Isukapalli S., Roy A. and Georgopoulos P.G. (2000). Efficient sensitivity/uncertainty analysis using the combined Stochastic Response Surface Method (SRSM) and Automatic Differentiation for FORTRAN code (ADIFOR): Application to environmental and biological systems. Risk Analysis 20: 591-602. LINK OUT

1. Isukapalli S., Roy A. and Georgopoulos P.G. (2000). Efficient sensitivity/uncertainty analysis using the combined Stochastic Response Surface Method (SRSM) and Automatic Differentiation for FORTRAN code (ADIFOR): Application to environmental and biological systems. Risk Analysis 20: 591-602. LINK OUT
2. Broday D. and Georgopoulos P.G. (2001). Growth and deposition of hygroscopic particulate matter in the human lungs. Aerosol Science and Technology 34: 144-159. LINK OUT
3. Drossinos Y., Kevrekedis P.G. and Georgopoulos P.G. (2001). Translational invariance in nucleation theories: Theoretical formulation. Physical Review E 63: 036123.1-036123.13. LINK OUT
4. Georgopoulos P.G., Roy A., Yonone-Lioy M.J., Opiekun R.E. and Lioy P.J. (2001). Environmental copper: Its dynamics and human exposure issues. Journal of Toxicology and Environmental Health-Part B-Critical Reviews 4 (4): 341-394. LINK OUT
5. Balakrishnan S., Banerjee I., Georgopoulos P.G. and Ierapetritou M. (2002). Uncertainty considerations for describing complex reaction systems. AIChE Journal 48 (12): 2875-2889. LINK OUT
6. Weisel C., Cody R., Georgopoulos P., Purushothaman V., Weiss S., Bielory L., Gregory P. and Stern A. (2002). Concepts in developing health-based indicators for ozone. International Archives of Occupational and Environmental Health 75 (6): 415-422. LINK OUT
7. Balakrishnan S., Roy A., Ierapetritou M.G., Flach G.P. and Georgopoulos P.G. (2003). Uncertainty reduction and characterization for complex environmental fate and transport models: An empirical Bayesian framework incorporating the stochastic response surface method. Water Resources Research 39 (12): 1350. LINK OUT
8. Foley G., Georgopoulos P.G. and Lioy P.J. (2003). Examining Accountability for Changes in Population Exposures to 8-Hour Ozone Standard With Implementation of Different Control Strategies. Environmental Science and Technology 37 (21): 302A-309A. LINK OUT
9. Li G., Artamonov M., Rabitz H., Wang S.W., Georgopoulos P.G. and Demiralp M. (2003). High Dimensional Model Representations generated from low order terms – 1p-RS-HDMR. Journal of Computational Chemistry 24: 647-656. LINK OUT
10. Li G., Rabitz H., Wang S.W. and Georgopoulos P.G. (2003). Correlation method for variance reduction of Monte Carlo integration in RS-HDMR. Journal of Computational Chemistry 24: 277-283. LINK OUT
11. Roy A., Ouyang M., Freeman N., Georgopoulos P.G. and Lioy P.J. (2003). Environmental, dietary, demographic, and activity variables associated with biomarkers of exposure for benzene and lead. Journal of Exposure Analysis and Environmental Epidemiology 13 (6): 417-426. LINK OUT
12. Wang S.W., Georgopoulos P.G., Li G. and Rabitz H. (2003). Random Sampling-High Dimensional Model Representation (RS-HDMR) with nonuniformly distributed variables: Application to an integrated multimedia/multipathway exposure and dose model for trichloroethylene. Journal of Physical Chemistry A 107 (23): 4707-4716. LINK OUT
13. Georgopoulos P.G., Fedele P., Shade P., Lioy P., Hodgson M., Longmire J., Sands M. and Brown M.A. (2004). Hospital response to chemical terrorism: Personal protective equipment, training, and operations planning. American Journal of Industrial Medicine 46: 432-445. LINK OUT
14. Huber A., Georgopoulos P., Gilliam R., Stenchikov G., Wang S.-W., Kelly B. and Feingersh H. (2004). Modeling Air Pollution from the Collapse of the World Trade Center and Assessing the Potential Impacts on Human Exposures. Environmental Manager February 2004: 35-40.
15. Landrigan P.J., Lioy P.J., Thurston G., Berkowitz G., Chen L.C., Chillrud S.N., Gavett S.H., Georgopoulos P.G., Geyh A.S., Levin S., Perera F., Rappaport S.M. and Small C. (2004). Health and environmental consequences of the World Trade Center disaster. Environmental Health Perspectives 112 (6): 731-739. LINK OUT
16. Lazaridis M., Spyridaki A., Solberg S., Kallos G., Svendby T., Flatøy F., Drossinos I., Housiadas C., Smolik J., Colbeck I., Varinou M., Gofa F., Eleftheriadis K., Zdimal V. and Georgopoulos P.G. (2004). Modeling of Combined Aerosol and Photooxidant Processes in the Mediterranean Area. Water, Air, and Soil Pollution: Focus V4 (4): 3-21. LINK OUT
17. Ouyang M., Welsh W.J. and Georgopoulos P. (2004). Gaussian mixture clustering and imputation of microarray data. Bioinformatics 20 (6): 917-23. LINK OUT
18. Vette A., Gavett S., Perry S., Heist D., Huber A., Lorber M., Lioy P., Georgopoulos P., Rao S.T., Petersen W., Hicks B., Irwin J. and Foley G. (2004). Environmental Research in Response to 9/11 and Homeland Security. Environmental Manager February 2004: 14-22.
19. Vyas V.M., Tong S.N., Uchrin C., Georgopoulos P.G. and Carter G.R. (2004). Geostatistical estimation of horizontal hydraulic conductivity for the Kirkwood-Cohansey aquifer. Journal of the American Water Resources Association 40 (1): 187-195. LINK OUT
20. Balakrishnan S., Roy A., Ierapetritou M.G., Flach G.P. and Georgopoulos P.G. (2005). A comparative assessment of efficient uncertainty analysis techniques for environmental fate and transport models: Application to the FACT model. Journal of Hydrology 307 (1-4): 204–218. LINK OUT
21. Georgopoulos P.G., Wang S.W., Vyas V.M., Sun Q., Burke J., Vedantham R., McCurdy T. and Ozkaynak H. (2005). A source-to-dose assessment of population exposures to fine PM and ozone in Philadelphia, PA, during a summer 1999 episode. Journal of Exposure Analysis and Environmental Epidemiology 15 (5): 439−457. LINK OUT
22. Lazaridis M., Spyridaki A., Solberg S., Smolik J., Zdimal V., Eleftheriadis K., Aleksaropoulou V., Hov O. and Georgopoulos P.G. (2005). Mesoscale modeling of combined aerosol and photo-oxidant processes in the Eastern Mediterranean. Atmospheric Chemistry and Physics 5: 927-940. LINK OUT
23. Wang S.W., Balakrishnan S. and Georgopoulos P.G. (2005). Fast Equivalent Operational Model of Tropospheric Alkane Photochemistry. AIChE Journal 51 (4): 1297-1303. LINK OUT
24. Wang S.W., Georgopoulos P.G., Li G. and Rabitz H. (2005). Characterizing uncertainties in human exposure modeling through the Random Sampling-High Dimensional Model Representation (RS-HDMR) methodology. International Journal of Risk Assessment and Management 5: 387-406. LINK OUT
25. Wintermyer M., Skiadas A., Roy A., Yang Y.C., Georgopoulos P., Burger J. and Cooper K. (2005). The development of a physiologically-based pharmacokinetic model using the distribution of 2 317 8-tetrachlorodibenzo-p-dioxin in the tissues of the eastern oyster (Crassostrea virginica). Marine Environmental Research 60 (2): 133-152. LINK OUT
26. Wolff M.S., Teitelbaum S.L., Lioy P.J., Santella R.M., Wang R.Y., Jones R.L., Caldwell K.L., Sjodin A., Turner W.E., Li W., Georgopoulos P. and Berkowitz G.S. (2005). Exposures among pregnant women near the World Trade Center site on 11 September 2001. Environmental Health Perspectives 113 (6): 739-48. LINK OUT
27. Georgopoulos P.G. and Lioy P.J. (2006). From theoretical aspects of human exposure and dose Assessment to computational model implementation: The MOdeling ENvironment for TOtal Risk studies (MENTOR). Journal of Toxicology and Environmental Health - Part B, Critical Reviews 9 (6): 457-483. LINK OUT
28. Georgopoulos P.G., Wang S.W., Lioy P.J., Georgopoulos I.G. and Yononne-Lioy M.J. (2006). Assessment of human exposure to copper: A case study using the NHEXAS database. Journal of Exposure Science and Environmental Epidemiology 16: 397-409. LINK OUT
29. Hore P., Zartarian V., Xue J., Özkaynak H., Wang S.-W., Yang Y.-C., Chu P.-L., Sheldon L., Robson M., Needham L., Barr D., Freeman N., Georgopoulos P. and Lioy P.J. (2006). Children’s residential exposure to chlorpyrifos: Application of CPPAES field measurements of chlorpyrifos and TCPy within MENTOR/SHEDS pesticides model. Science of The Total Environment 366 (2-3): 525-537. LINK OUT
30. Li G., Hu J., Wang S.W., Georgopoulos P.G., Schoendorf J. and Rabitz H. (2006). Random Sampling-High Dimensional Model Representation (RS-HDMR) and orthogonality of its different order component functions. Journal of Physical Chemistry A 110 (7): 2474-2485. LINK OUT
31. Lioy P.J. and Georgopoulos P. (2006). The anatomy of the exposures that occurred around the World Trade Center site: 9/11 and beyond. Annals of the New York Academy of Sciences 1076 (1): 54-79. LINK OUT
32. Stenchikov G., Lahoti N., Diner D.J., Kahn R., Lioy P.J. and Georgopoulos P.G. (2006). Multiscale plume transport from the collapse of the World Trade Center on September 11, 2001. Environmental Fluid Mechanics 6 (5): 425-450. LINK OUT
33. Vyas V.M., Roy A., Strawderman W., Georgopoulos P.G. and Kosson D.S. (2006). Development and application of methodologies for determining background groundwater quality at the Savannah River site. Journal of the Air and Waste Management Association 56 (2): 159-168. LINK OUT
34. Vyas V.M., Sussman N., Gochfeld M., Georgopoulos P.G. and Lioy P.J. (2006). An evaluation of the role of risk based decision making in a former manufactured gas plant site remediation. Journal of the Air and Waste Management Association 56 (2): 225-235. LINK OUT
35. Lioy P.J., Vallero D., Foley G., Georgopoulos P., Heiser J., Watson T., Reynolds M., Daloia J., Tong S. and Isukapalli S. (2007). A personal exposure study employing scripted activities and paths in conjunction with atmospheric releases of perfluorocarbon tracers in Manhattan, New York. Journal of Exposure Science and Environmental Epidemiology 17 (5): 409-425. LINK OUT
36. Georgopoulos P. (2008). A multiscale approach for assessing the interactions of environmental and biological systems in a holistic health risk assessment framework. Water, Air, and Soil Pollution: Focus 8 (1): 3-21. LINK OUT
37. Georgopoulos P.G., Sasso A.F., Isukapalli S.S., Lioy P.J., Vallero D.A., Okino M. and Reiter L. (2008). Response to "µg/kg-day or µg/day: A commentary on Georgopoulos et al., JESEE 2008". J Expos Sci Environ Epidemiol 18 (6): 536-537. LINK OUT
38. Georgopoulos P.G., Wang S.-W., Yang Y.-C., Xue J., Zartarian V.G., McCurdy T. and Ozkaynak H. (2008). Biologically based modeling of multimedia, multipathway, multiroute population exposures to arsenic. Journal of Exposure Science and Environmental Epidemiology 18 (5): 462-476. LINK OUT
39. Isukapalli S.S., Lioy P.J. and Georgopoulos P.G. (2008). Mechanistic modeling of emergency events: Assessing the impact of hypothetical releases of anthrax. Risk Analysis 28 (3): 723-740. LINK OUT
40. Zhu X., Fan Z., Wu X., Meng Q., Wang S.-W., Tang X., Ohman-Strickland P., Georgopoulos P., Zhang J., Bonanno L., Held J. and Lioy P. (2008). Spatial variation of volatile organic compounds in a "Hot Spot" for air pollution. Atmospheric Environment 42 (32): 7329-7338 LINK OUT
41. Chen M., Martin J., Fang H., Isukapalli S., Georgopoulos P.G., Welsh W.J. and Tong W. (2009). ebTrack: an environmental bioinformatics system built upon ArrayTrack. BMC Proceedings 3 (Suppl 2): S5. LINK OUT
42. Georgopoulos P., Isukapalli S., Burke J., Napelenok S., Palma T., Langstaff J., Majeed M., He S., Byun D., Cohen M. and Vautard R. (2009). Air quality modeling needs for exposure assessment from the source-to-outcome perspective. Environmental Manager(October): 26-35. LINK OUT
43. Georgopoulos P.G. and Isukapalli S.S. (2009). A unified multiscale field/network/agent based modeling framework for human and ecological health risk analysis. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society 1: 6420-6423. LINK OUT
44. Georgopoulos P.G., Sasso A.F., Isukapalli S.S., Lioy P.J., Vallero D.A., Okino M. and Reiter L. (2009). Reconstructing population exposures to environmental chemicals from biomarkers: Challenges and opportunities. Journal of Exposure Science and Environmental Epidemiology 19 (2): 149-171. LINK OUT
45. Gerecke D., Chen M., Isukapalli S., Gordon M.K., Chang Y.-C., Tong W., Androulakis I. and Georgopoulos P.G. (2009). Differential gene expression profiling of mouse skin after sulfur mustard exposure: extended time response and inhibitor effect. Toxicology and Applied Pharmacology 234 (2): 156-165. LINK OUT
46. Ierapetritou M.G., Georgopoulos P.G., Roth C.M. and Androulakis I.P. (2009). Tissue-level modeling of xenobiotic metabolism in liver: An emerging tool for enabling clinical translational research. Clinical and Translational Science 2 (3): 228 - 237. LINK OUT
47. Laumbach R., Harris G., Kipen H., Georgopoulos P., Shade P., Isukapalli S., Efstathiou C., Galea S., Vlahov D. and Wartenberg D. (2009). Lack of association between estimated World Trade Center plume intensity and respiratory symptoms among New York City residents outside of Lower Manhattan. American Journal of Epidemiology 170 (5): 640-649. LINK OUT
48. Lioy P.J., Isukapalli S., Trasande L., Thorpe L., Dellarco M., Weisel C., Georgopoulos P.G., Yung C., Brown M. and Landrigan P. (2009). Using national and local extant data to characterize environmental exposures in the National Children’s Study (NCS): Queens County, New York. Environmental Health Perspectives 117 (10): 1494-1504. LINK OUT
49. Wang S.-W., Tang X., Fan Z., Lioy P.J. and Georgopoulos P.G. (2009). Modeling personal exposures from ambient air toxics in Camden, New Jersey: An evaluation study. Journal of the Air and Waste Management Association 59: 733-746. LINK OUT
50. Sasso A., Isukapalli S. and Georgopoulos P. (2010). A generalized physiologically-based toxicokinetic modeling system for chemical mixtures containing metals. Theoretical Biology and Medical Modelling 7 (1): 17. LINK OUT
51. Xue J., Zartarian V., Wang S.W., Liu S.V. and Georgopoulos P.G. (2010). Probabilistic modeling of dietary arsenic exposure and dose and validation with 2003 NHANES data. Environmental Health Perspectives 118 (3): 345-350. LINK OUT
52. Yang Y., Xu X. and Georgopoulos P.G. (2010). A Bayesian population PBPK model for multiroute chloroform exposure. Journal of Exposure Science and Environmental Epidemiology 20 (4): 326-341. LINK OUT
53. Sasso A., Isukapalli S. and Georgopoulos P. (2010). A generalized physiologically-based toxicokinetic modeling system for chemical mixtures containing metals. Theoretical Biology and Medical Modelling 7 (1): 17. LINK OUT
54. Hogrefe C., Isukapalli S.S., Tang X., Georgopoulos P.G., He S., Zalewsky E.E., Hao W., Ku J.-Y., Key T. and Sistla G. (2011). Impact of biogenic emission uncertainties on the simulated response of O3 and PM2.5 to anthropogenic emission reductions. Journal of the Air and Waste Management Association 61: 92-108. LINK OUT
55. Efstathiou C., Isukapalli S.S. and Georgopoulos P.G. (2011). A mechanistic modeling system for estimating large scale emissions and transport of pollen and co-allergens. Atmospheric Environment 45(13): 2260-2276. LINK OUT
56. Stamatelos S.K., Brinkerhoff C.J., Isukapalli S.S. and Georgopoulos P.G. (2011). Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes – Incorporation of cellular antioxidant response and threshold-dependent behavior. BMC Systems Biology 5 (16). LINK OUT
57. Carter G.P., Miskewitz R.J., Isukapalli S., Mun Y., Vyas V., Yoon S., Georgopoulos P. and Uchrin C.G. (2011). Comparison of kriging and cokriging for the geostatistical estimation of specific capacity in the Newark Basin (NJ) aquifer system. Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances and Environmental Engineering 46 (4): 371-377. LINK OUT

Peer Reviewed Book Chapters (selected from the past 10 years)

1. Cohen M., Sunderland E., Georgopoulos P.G., Wang S.W., Isukapalli S., Yang Y.C., Sasso A., Tong S., Xue J., McCurdy T., Zhang M., Sheldon L. and International Air Quality Advisory Board (2006). Development of a multicompartment mercury model for Lake Ontario: Tracking mercury from sources, deposition, and dispersion to fish to accumulation in humans. In Priorities 2005 - Priorities and Progress Under the Great Lakes Water Quality Agreenent Windsor, Ontario, Canada, International Joint Commission (IJC): pp. 39–69. LINK OUT
2. Lioy P.J., Weisel C. and Georgopoulos P.G. (2006). An Overview of the Environmental Conditions and Human Exposures that Occurred Post 9-11. In Urban Aerosols and Their Impacts: Lessons Learned from the World Trade Center Tragedy. Gaffney, J. S. and Marley, N. A. (eds.) Washington DC, ACS Symposium Book, Oxford University Press: pp. 23–38
3. Isukapalli S.S. and Roy A. (2007). General principles of programming (computer and statistical). In Pharmacometrics: the Science of Quantitative Pharmacology. Ette, E. I. and Williams, P. J. (eds.), Wiley: pp. 25–52. LINK OUT
4. Isukapalli S.S., Roy A. and Georgopoulos P.G. (2007). Physiologically Based Pharmacokinetic Modeling: Inhalation, Ingestion, and Dermal Absorption. In Pharmacometrics: the Science of Quantitative Pharmacology. Ette, E. I. and Williams, P. J. (eds.), Wiley: pp. 1069–1108. LINK OUT
5. Welsh W.J., Tong W. and Georgopoulos P.G. (2007). Toxicoinformatics: An Introduction. In Computational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals. Ekins, S.
   Sean Ekins
   Sean Ekins is a British pharmacologist and expert in the fields of ADME/Tox, computational toxicology and cheminformatics at Collaborations in Chemistry, a division of corporate communications firm Collaborations in Communications...
   
   (ed.), Wiley: pp. 153–182. LINK OUT
6. Fan Z., Lioy P.J. and Wang S.-W. (2008). Ambient Air Quality Monitoring and Community Air Sampling. In Air Sampling Technologies: Principles and Applications Cincinnati, OH, American Conference of Governmental Industrial Hygienists (ACGIH). LINK OUT
7. Krishnan K., Isukapalli S. and Boyd J. (2009). Evaluation of toxicological interactions for the dose-response assessment of chemical mixtures (Chapter 9). In General and Applied Toxicology. Ballantyne, B., Marrs, T. C. and Syversen, T. (eds.), Wiley/Blackwell. LINK OUT
8. Georgopoulos P.G., Isukapalli S. and Krishnan K. (2010). Modeling exposures to chemicals from multiple sources and routes. In Quantitative Modeling in Toxicology. Krishnan, K. and Andersen, M. E. (eds.), John Wiley: pp. 315–351. LINK OUT
9. Isukapalli S., Spendiff M., Georgopoulos P.G. and Krishnan K. (2010). Uncertainty, variability and sensitivity analyses in simulation models. In Quantitative Modeling in Toxicology. Krishnan, K. and Andersen, M. E. (eds.), John Wiley: pp. 429–458. LINK OUT
10. Vallero D., Isukapalli S., Zartarian V., McCurdy T., McKone T., Georgopoulos P.G. and Dary C. (2010). Modeling and predicting pesticide exposures. Chapter 44. In Hayes’ Handbook of Pesticide Toxicology - Third Edition. Krieger, R. (ed.), Academic Press: pp. 995–1020. LINK OUT
11. Isukapalli S.S., Bielory L. and Georgopoulos P.G. (2011). Modeling effects of climate change on allergic illness. In McGraw-Hill Yearbook of Science and Technology 2011 New York, McGraw-Hill: pp.205-208
12. Krishnan K., Sasso A. and Georgopoulos P.G. (2010). Pharmacokinetic mechanisms of interactions in chemical mixtures. In Principles and Practice of Mixture Toxicology. Mumtaz, M. (ed.), John Wiley Publishers: pp. 159–176. LINK OUT
13. Georgopoulos P.G., Isukapalli S., Androulakis I.P., Ierapetritou M.G. and Welsh W.J. (2011). Multiscale integration of toxicokinetic and toxicodynamic processes: From cell and tissue to organ and "whole body" models. In Handbook of Systems Toxicology. Casciano, D. and Sahu, S. (eds.), John Wiley. pp. 619-668 LINK OUT

Government Reports

1. Isukapalli S.S. and Georgopoulos P.G. (2001). Computational Methods for Sensitivity and Uncertainty Analysis for Environmental and Biological Models. Research Triangle Park, NC. Prepared for the US Environmental Protection Agency National Exposure Research Laboratory. EPA/600/R-01-068 (145 pp.). LINK OUT
2. Small M.J., Anderson H.A., Bartell S.M., Chien C., Greer L.E., Liu K.S., Mauderly J.L., Middleton P., Brown D.R., Gentile T.J., Georgopoulos P.G., Henry C.J., Millford J., Kooyoomjian K.J. and Fortune B.B. (2001). NATA - Evaluating the National-Scale Air Toxics Assessment 1996 Data - an SAB Advisory. Prepared for US EPA's Science Advisory Board. EPA-SAB-EC-ADV-02-001 (62 pp. plus appendices)
3. USEPA (2006). Draft Guidance on the Development, Evaluation, and Application of Regulatory Environmental Models and Models Knowledge Base [P.G. Georgopoulos, Contributor] Washington DC. Regulatory Environmental Modeling Guidance Review Panel, EPA Science Advisory Board. EPA-SAB-06-009. LINK OUT
4. Kotchmar D.J., Ross M., Belanger K., Brown J.S., Bryant D., Cote I., Frampton M., Gent J., Hasselblad V., Ito K., Kim J.Y., Kirrane E., Luben T., Maier A., Meng Q., Pinto J., Reinhart P., Svendsgaard D., White L., Allen D., Arnold J., Camalier L., Dickerson R., Fan T., Fiore A., Georgopoulos P., Horowitz L., Keene W., Martin R., Morandi M., Munger W., Piety C., Sillman S., Suh H., Walsh D., Wechsler C., Weisel C. and Zhang J. (2007). Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (First External Review Draft). Research Triangle Park, NC. USEPA National Center for Environmental Assessment. EPA/600/R-07/093 (371 pages). LINK OUT
5. USEPA (2007). Report on the External Peer Review Workshop of EPA’s Draft Document Child-Specific Exposure Factors Handbook [P.G. Georgopoulos, Contributor] Washington DC. US Environmental Protection Agency (80 pages)
6. USEPA (2008). Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (Final) [P.G. Georgopoulos, Contributor] Research Triangle Park, NC. USEPA National Center for Environmental Assessment. EPA/600/R-08/07 (260 pages). LINK OUT
7. USEPA (2008). Integrated Science Assessment for Sulfur Oxides – Health Criteria (Final Report). Washington, DC. US Environmental Protection Agency. EPA/600/R-08/047F (479 pages). LINK OUT

Books

1. Georgopoulos P.G., Roy A., Yonone-Lioy M.J., Opiekun R.E. and Lioy P.J. (2002). Environmental Dynamics and Human Exposure to Copper Volume 1: Environmental Dynamics and Human Exposure Issues. New York, NY, International Copper Association. ISBN 0-943642-12-13
2. Georgopoulos P.G., Wang S.W., Vyas V.M., Lioy P.J., Tan H.C., Georgopoulos I.G. and Yonnone-Lioy J. (2002). Environmental Dynamics and Human Exposure to Copper Volume 2: Framework and Data Sources for Assessing Human Exposure to Copper in the United States. New York, NY, International Copper Association. ISBN 0-943642-12-14

External links

• Computational Chemodynamics Laboratory
• environmental bioinformatics and Computational Toxicology Center
• Elytis Chair Fund