Paramethadione
Encyclopedia
Paramethadione is an anticonvulsant
in the oxazolidinedione
class. It is associated with fetal trimethadione syndrome
, which is also known as paramethadione syndrome.
only in the substitution of one methyl group with an ethyl group. It is synthesized in a completely analogous manner, except that it comes from 2-hydroxy-2-methylbutyric acid instead of 2-hydroxyisobutyric acid.
Anticonvulsant
The anticonvulsants are a diverse group of pharmaceuticals used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of bipolar disorder, since many seem to act as mood stabilizers, and in the treatment of neuropathic pain. The goal of an...
in the oxazolidinedione
Oxazolidinedione
Oxazolidinedione is a heterocyclic chemical compound that forms the core structure of a variety anticonvulsant drugs including:* Ethadione* Paramethadione* Trimethadione...
class. It is associated with fetal trimethadione syndrome
Fetal trimethadione syndrome
Fetal trimethadione syndrome is a set of birth defects caused by the administration of the anticonvulsants trimethadione or paramethadione to epileptic mothers during pregnancy.Fetal trimethadione syndrome is classified as a rare disease by the National...
, which is also known as paramethadione syndrome.
Chemistry
Paramethadione, 5-ethyl-3,5-dimethyloxazolidine-2,4-dione, differs from trimethadioneTrimethadione
Trimethadione is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.-Fetal trimethadione syndrome:...
only in the substitution of one methyl group with an ethyl group. It is synthesized in a completely analogous manner, except that it comes from 2-hydroxy-2-methylbutyric acid instead of 2-hydroxyisobutyric acid.
- M.A. Spielman, (1951).