The Patuxet are an extinct Native American tribe of the Wampanoag tribal confederation. They lived primarily in and around the area of what has since been settled as Plymouth, Massachusetts.
The Patuxet were wiped out by a series of plagues

Pandemic

A pandemic is an epidemic of infectious disease that is spreading through human populations across a large region; for instance multiple continents, or even worldwide. A widespread endemic disease that is stable in terms of how many people are getting sick from it is not a pandemic...

 that decimated the indigenous peoples of southeastern New England

New England

New England is a region in the northeastern corner of the United States consisting of the six states of Maine, New Hampshire, Vermont, Massachusetts, Rhode Island, and Connecticut...

 in the second decade of the 17th century. The epidemics which swept across New England and the Canadian Maritimes between 1614 and 1620 were especially devastating to the Wampanoag and neighboring Massachuset, with mortality

Mortality rate

Mortality rate is a measure of the number of deaths in a population, scaled to the size of that population, per unit time...

 reaching 100% in many mainland villages.