Pazinaclone
Encyclopedia
Pazinaclone is a sedative
and anxiolytic
drug in the cyclopyrrolone family of drugs. Other cyclopyrrolone drugs include zopiclone
and eszopiclone
.
Pazinaclone has a very similar pharmacological profile to the benzodiazepine
family of drugs including sedative and anxiolytic properties, but with less amnestic effects, and at low doses it is a relatively selective anxiolytic, with sedative effects only appearing at higher doses.
Pazinaclone produces its sedative and anxiolytic effects by acting as a partial agonist
at GABAA benzodiazepine receptors, although pazinaclone is more subtype-selective than most benzodiazepines.
Sedative
A sedative or tranquilizer is a substance that induces sedation by reducing irritability or excitement....
and anxiolytic
Anxiolytic
An anxiolytic is a drug used for the treatment of anxiety, and its related psychological and physical symptoms...
drug in the cyclopyrrolone family of drugs. Other cyclopyrrolone drugs include zopiclone
Zopiclone
Zopiclone is a non-benzodiazepine hypnotic agent used in the treatment of insomnia. In the United States, zopiclone is not commercially available, although its active stereoisomer, eszopiclone, is sold under the name Lunesta...
and eszopiclone
Eszopiclone
Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic used as a treatment for insomnia. Eszopiclone is the active dextrorotatory stereoisomer of zopiclone, and belongs to the class of drugs known as cyclopyrrolones.Eszopiclone is a short acting...
.
Pazinaclone has a very similar pharmacological profile to the benzodiazepine
Benzodiazepine
A benzodiazepine is a psychoactive drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring...
family of drugs including sedative and anxiolytic properties, but with less amnestic effects, and at low doses it is a relatively selective anxiolytic, with sedative effects only appearing at higher doses.
Pazinaclone produces its sedative and anxiolytic effects by acting as a partial agonist
Partial agonist
Partial agonists bind and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist...
at GABAA benzodiazepine receptors, although pazinaclone is more subtype-selective than most benzodiazepines.