Pennsylvania Route 80 was a 96 miles (154.5 km) long east–west state highway

State highway

State highway, state road or state route can refer to one of three related concepts, two of them related to a state or provincial government in a country that is divided into states or provinces :#A...

 in western Pennsylvania

Pennsylvania

The Commonwealth of Pennsylvania is a U.S. state that is located in the Northeastern and Mid-Atlantic regions of the United States. The state borders Delaware and Maryland to the south, West Virginia to the southwest, Ohio to the west, New York and Ontario, Canada, to the north, and New Jersey to...

. The western terminus of the route was at Interstate 70, U.S. Route 22, and U.S. Route 30 in Pittsburgh

Pittsburgh, Pennsylvania

Pittsburgh is the second-largest city in the US Commonwealth of Pennsylvania and the county seat of Allegheny County. Regionally, it anchors the largest urban area of Appalachia and the Ohio River Valley, and nationally, it is the 22nd-largest urban area in the United States...

. The eastern terminus was at U.S. Route 219 northeast of Glen Campbell

Glen Campbell, Pennsylvania

Glen Campbell is a borough in Indiana County, Pennsylvania, United States. The population was 306 at the 2000 census. The borough was named in 1889 for Cornelius Campbell, the first superintendent of the Glenwood Coal Company , which mined in that area.The modern singer Glen Campbell visited Glen...

.

The route was deleted in 1961 and replaced by Pennsylvania Route 380

Pennsylvania Route 380

Pennsylvania Route 380 , also known as J.F. Bonetto Memorial Highway, is a long state highway in western portions of the U.S. state of Pennsylvania. The western terminus of the route is at Interstate 579 in downtown Pittsburgh near Mellon Arena...

 from US 22/US 30 to Dallas Avenue in Pittsburgh, Pennsylvania Route 8

Pennsylvania Route 8

Pennsylvania Route 8 is a major long route in western Pennsylvania. Officially, PA 8 is named the William Flinn Highway. Its southern terminus is at Interstate 376, U.S. Route 22, and U.S. Route 30 in Pittsburgh...

 from Dallas Avenue to US 22 exit 8 in Wilkinsburg

Wilkinsburg, Pennsylvania

Wilkinsburg is a borough in Allegheny County, Pennsylvania, United States adjacent to the city of Pittsburgh. The population was 15,930 at the 2010 census, having lost more than 13,000 in the 70 years since 1940, when 29,853 people were enumerated...

, US 22 from Wilkinsburg to Pennsylvania Route 286

Pennsylvania Route 286

Pennsylvania Route 286 is an long, east–west state highway located in Allegheny, Westmoreland, Indiana, and Clearfield counties in Pennsylvania. The western terminus is at US 22 in Monroeville. The eastern terminus is at US 219 near Burnside....

and PA 286 from US 22 to US 219.