Phosducin family
Encyclopedia
The outer and inner segments of vertebrate retina
rod photoreceptor cells contain phosducin
, a soluble phosphoprotein
that complexes with the beta/gamma-subunits of the guanosine triphosphate
-binding protein, transducin
. Light-induced changes in cyclic nucleotide levels modulate the phosphorylation
of phosducin by protein kinase A. The protein is thought to participate in the regulation of visual phototransduction or in the integration of photo-receptor metabolism. Similar proteins have been isolated from the pineal gland
and it is believed that the function of the protein is the same in both retina and pineal gland.
Retina
The vertebrate retina is a light-sensitive tissue lining the inner surface of the eye. The optics of the eye create an image of the visual world on the retina, which serves much the same function as the film in a camera. Light striking the retina initiates a cascade of chemical and electrical...
rod photoreceptor cells contain phosducin
Phosducin
Phosducin, also known as PDC, is a human protein and gene. It belongs to phosducin family of proteins.-Further reading:...
, a soluble phosphoprotein
Phosphoprotein
Phosphoproteins are proteins that are physically bonded to a substance containing phosphoric acid . This category of organic molecules includes Fc receptors, Ulks, Calcineurins, K chips, and urocortins....
that complexes with the beta/gamma-subunits of the guanosine triphosphate
Guanosine triphosphate
Guanosine-5'-triphosphate is a purine nucleoside triphosphate. It can act as a substrate for the synthesis of RNA during the transcription process...
-binding protein, transducin
Transducin
Transducin is a heterotrimeric G protein that is naturally expressed in vertebrate retina rods and cones .- Mechanism of action :...
. Light-induced changes in cyclic nucleotide levels modulate the phosphorylation
Phosphorylation
Phosphorylation is the addition of a phosphate group to a protein or other organic molecule. Phosphorylation activates or deactivates many protein enzymes....
of phosducin by protein kinase A. The protein is thought to participate in the regulation of visual phototransduction or in the integration of photo-receptor metabolism. Similar proteins have been isolated from the pineal gland
Pineal gland
The pineal gland is a small endocrine gland in the vertebrate brain. It produces the serotonin derivative melatonin, a hormone that affects the modulation of wake/sleep patterns and seasonal functions...
and it is believed that the function of the protein is the same in both retina and pineal gland.
Human proteins containing this domain
Gene | Aliases | Protein |
---|---|---|
PDC Phosducin Phosducin, also known as PDC, is a human protein and gene. It belongs to phosducin family of proteins.-Further reading:... |
MEKA | phosducin |
PDCL | PhLP1 | phosducin-like |
PDCL2 | GCPHLP | phosducin-like 2 |
PDCL3 | PhLP2A | phosducin-like 3 |
TXNDC9 TXNDC9 Thioredoxin domain-containing protein 9 is a protein that in humans is encoded by the TXNDC9 gene.-Further reading:... |
PhLP3 | thioredoxin domain containing 9 |