Pier Paolo Pandolfi
Encyclopedia
Dr. Pier Paolo Pandolfi (born May 14, 1963 in Rome, Italy) is an award-winning research geneticist
at Beth Israel Deaconess Medical Center
, a major teaching hospital of Harvard Medical School
. The research carried out in Dr. Pandolfi’s laboratory has been seminal in defining the molecular mechanisms and the genetics underlying the pathogenesis of APL
, lymphoma
s, and solid tumors, as well as in modeling these cancers in the mouse. Dr. Pandolfi and colleagues characterized the function of the fusion oncoproteins of APL, of the genes involved in the chromosomal translocations of APL, as well as of major tumor suppressors such PTEN
, PML
, and p53
. The elucidation of the molecular basis underlying APL pathogenesis has led to the development of novel therapeutic strategies that are currently being tested in clinical trials.
, Italy. He received post-graduate training at the National Institute for Medical Research
and the University of London
in the United Kingdom
.
; Professor, Molecular Biology in Pathology and Laboratory Medicine, Weill Medical College at Cornell University
; he was head of the Molecular and Developmental Biology Laboratory at MSKCC. Dr. Pandolfi has recently been bestowed the Albert C. Foster Endowed Chair for Cancer Research at Memorial Sloan-Kettering Cancer Center
.
In September 2007, Pandolfi began new appointments at Beth-Israel Deaconess Medical Center in the departments of Medicine and Pathology. He was named Director of the Cancer Genetics program as well as Associate Director of Basic Research for BIDMC's Cancer Center. He will also begin his appointment as Professor of Medicine and Pathology at Harvard Medical School
.
Geneticist
A geneticist is a biologist who studies genetics, the science of genes, heredity, and variation of organisms. A geneticist can be employed as a researcher or lecturer. Some geneticists perform experiments and analyze data to interpret the inheritance of skills. A geneticist is also a Consultant or...
at Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center in Boston, Massachusetts is a major flagship teaching hospital of Harvard Medical School. It was formed out of the 1996 merger of Beth Israel Hospital and New England Deaconess Hospital...
, a major teaching hospital of Harvard Medical School
Harvard Medical School
Harvard Medical School is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts....
. The research carried out in Dr. Pandolfi’s laboratory has been seminal in defining the molecular mechanisms and the genetics underlying the pathogenesis of APL
Acute promyelocytic leukemia
Acute promyelocytic leukemia is a subtype of acute myelogenous leukemia , a cancer of the blood and bone marrow. It is also known as acute progranulocytic leukemia; APL; AML with t, PML-RARA and variants; FAB subtype M3 and M3 variant.In APL, there is an abnormal accumulation of immature...
, lymphoma
Lymphoma
Lymphoma is a cancer in the lymphatic cells of the immune system. Typically, lymphomas present as a solid tumor of lymphoid cells. Treatment might involve chemotherapy and in some cases radiotherapy and/or bone marrow transplantation, and can be curable depending on the histology, type, and stage...
s, and solid tumors, as well as in modeling these cancers in the mouse. Dr. Pandolfi and colleagues characterized the function of the fusion oncoproteins of APL, of the genes involved in the chromosomal translocations of APL, as well as of major tumor suppressors such PTEN
PTEN
PTEN may mean:* Patterson-UTI Energy, Inc., which trades on the NASDAQ stock market under the symbol 'PTEN'* Prime Time Entertainment Network* PTEN , a human tumour suppressor gene on chromosome 10...
, PML
PML
PML may refer to:* Pakistan Muslim League, faction of the Pakistani political parties with similar names* Partido Movimiento Libertario, libertarian political party in Costa Rica* Perfectly Matched Layer, numerical truncation methodology....
, and p53
P53
p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
. The elucidation of the molecular basis underlying APL pathogenesis has led to the development of novel therapeutic strategies that are currently being tested in clinical trials.
Education
Pandolfi received his M.D. in 1989, and his Ph.D. in 1995, from the University of PerugiaUniversity of Perugia
University of Perugia is a public-owned university based in Perugia, Italy. It was founded in 1308, as attested by the Bull issued by Pope Clement V certifying the birth of the Studium Generale....
, Italy. He received post-graduate training at the National Institute for Medical Research
National Institute for Medical Research
The National Institute for Medical Research, commonly abbreviated to NIMR, is a medical research facility situated in Mill Hill, on the outskirts of London, England. It is mainly funded by the Medical Research Council, or MRC, and is its largest establishment and the only one designated as an...
and the University of London
University of London
-20th century:Shortly after 6 Burlington Gardens was vacated, the University went through a period of rapid expansion. Bedford College, Royal Holloway and the London School of Economics all joined in 1900, Regent's Park College, which had affiliated in 1841 became an official divinity school of the...
in the United Kingdom
United Kingdom
The United Kingdom of Great Britain and Northern IrelandIn the United Kingdom and Dependencies, other languages have been officially recognised as legitimate autochthonous languages under the European Charter for Regional or Minority Languages...
.
Career
Pandolfi left his appointment of Member in the Cancer Biology and Genetics Program at the Sloan Kettering Institute in the Spring of 2007; Professor of Molecular Biology, Pathology and Human Genetics at the Weill Graduate School of Medical Sciences at Cornell UniversityCornell University
Cornell University is an Ivy League university located in Ithaca, New York, United States. It is a private land-grant university, receiving annual funding from the State of New York for certain educational missions...
; Professor, Molecular Biology in Pathology and Laboratory Medicine, Weill Medical College at Cornell University
Cornell University
Cornell University is an Ivy League university located in Ithaca, New York, United States. It is a private land-grant university, receiving annual funding from the State of New York for certain educational missions...
; he was head of the Molecular and Developmental Biology Laboratory at MSKCC. Dr. Pandolfi has recently been bestowed the Albert C. Foster Endowed Chair for Cancer Research at Memorial Sloan-Kettering Cancer Center
Memorial Sloan-Kettering Cancer Center
Memorial Sloan–Kettering Cancer Center is a cancer treatment and research institution founded in 1884 as the New York Cancer Hospital...
.
In September 2007, Pandolfi began new appointments at Beth-Israel Deaconess Medical Center in the departments of Medicine and Pathology. He was named Director of the Cancer Genetics program as well as Associate Director of Basic Research for BIDMC's Cancer Center. He will also begin his appointment as Professor of Medicine and Pathology at Harvard Medical School
Harvard Medical School
Harvard Medical School is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts....
.
Awards
Dr. Pandolfi has received numerous awards including the LLSA Scholar Award (1997), the Irma T. Hirschl Trust Award, the Alexandra J. Kefalides Prize for Leukemia Research (1999), the Hamdan Award for Medical Research Excellence (2000), the Lombroso Prize for Cancer Research of the Weizmann Institute of Science (2001), the Leukemia and Lymphoma Society’s Stohlman Scholar Award (2004), the William and Linda Steere Foundation Award and the prize for Scientific Excellence in Medicine from the American-Italian Cancer Foundation (2005). In 2006 Dr. Pandolfi was elected as a member of the American Society for Clinical Investigation and the American Association of Physicians. He also has recently been awarded the NIH MERIT Award for superior competence and outstanding productivity in research.External links
- Pier Paolo Pandolfi, M.D., Ph.D profile from Harvard UniversityHarvard UniversityHarvard University is a private Ivy League university located in Cambridge, Massachusetts, United States, established in 1636 by the Massachusetts legislature. Harvard is the oldest institution of higher learning in the United States and the first corporation chartered in the country...