Pir Muhammad was a grandson and appointed successor of Timur

Timur

Timur , historically known as Tamerlane in English , was a 14th-century conqueror of West, South and Central Asia, and the founder of the Timurid dynasty in Central Asia, and great-great-grandfather of Babur, the founder of the Mughal Dynasty, which survived as the Mughal Empire in India until...

. He was the son of Jahangir.

In 1392 he received the governorship of Qandahar. His territory extended from the lands west of the Hindu Kush

Hindu Kush

The Hindu Kush is an mountain range that stretches between central Afghanistan and northern Pakistan. The highest point in the Hindu Kush is Tirich Mir in the Chitral region of Khyber-Pakhtunkhwa, Pakistan.It is the westernmost extension of the Pamir Mountains, the Karakoram Range, and is a...

 to the Indus River

Indus River

The Indus River is a major river which flows through Pakistan. It also has courses through China and India.Originating in the Tibetan plateau of western China in the vicinity of Lake Mansarovar in Tibet Autonomous Region, the river runs a course through the Ladakh district of Jammu and Kashmir and...

. In the fall of 1397 he led the first wave of Timurids into India

India

India , officially the Republic of India , is a country in South Asia. It is the seventh-largest country by geographical area, the second-most populous country with over 1.2 billion people, and the most populous democracy in the world...

, and was invested with the rulership of Multan

Multan

Multan , is a city in the Punjab Province of Pakistan and capital of Multan District. It is located in the southern part of the province on the east bank of the Chenab River, more or less in the geographic centre of the country and about from Islamabad, from Lahore and from Karachi...

.

On his deathbed, Timur named Pir Muhammad as his successor. Timur felt that none of his sons were capable of handling the job (Jahangir and 'Umar Shaikh had died, Miran Shah

Miran Shah

Miran Shah was a son of Timur, and a Timurid governor during his father's lifetime.Miran Shah's first charge was a vast region centered around Qandahar, which he was granted in 1383. That same year, he destroyed a rebellion against Timurid authority by the Kartids, then vassals of Timur in...

 suffered from mental difficulties, and Shah Rukh

Shah Rukh (Timurid dynasty)

Shāhrukh Mīrzā was the ruler of the eastern portion of the empire established by the Central Asian warlord Timur - the founder of the Timurid dynasty - governing most of Persia and Transoxiana between 1405 and 1447...

 was judged too pious to rule). Unfortunately for Pir Muhammad, none of his relatives supported him following Timur's death. He was unable to assume command in Samarkand

Samarkand

Although a Persian-speaking region, it was not united politically with Iran most of the times between the disintegration of the Seleucid Empire and the Arab conquest . In the 6th century it was within the domain of the Turkic kingdom of the Göktürks.At the start of the 8th century Samarkand came...

and was murdered by his vizier in 1407.