Piretanide
Piretanide has been synthesized in 1973 at Hoechst AG (Germany) as a diuretic and
saluretic compound by using a new method for introducing cyclic amine residues in an
aromatic nucleus in the presence of other aromatically bonded functional groups like sulfamoyl-,
ester-,nitro-,amino-,hydroxy-,cyano-,halogen- or sulfonylimino-groups.
Intensive studies of piretanide in rats and dogs in comparison with other high-ceiling diuretics
e.g.furosemide and bumetanide revealed its diuretic and saluretic potency with a more
suitable dose/response (regression lines) and a more favourable Na/K excretion ratio.
These findings led eventually to clinical studies in man and finally to the introduction
as a saluretic and antihypertensive medication in Germany,France,Italy and other countries.
Trade names: ARELIX,Eurelix,Tauliz.
Bibliography :
W.Merkel,D.Bormann,D.Mania,R.Muschaweck and M.Hropot,EUR.J.MED.Chem.-ChIM.THER.11,399 (1976)
W.Merkel,D.Mania and D.Bormann,Liebigs Ann.Chem.461(1979)