Podocin is a protein component of the slit diaphragm of podocytes. Glomerular capillary endothelial cells, the glomerular basement membrane

Glomerular basement membrane

The glomerular basement membrane is the basal laminal portion of the glomerulus. The Glomerular capillary endothelial cells, the GBM and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that...

 and the slit diaphragms function as the filtration barrier of the kidney glomerulus

Glomerulus

A glomerulus is a capillary tuft that is involved in the first step of filtering blood to form urine.A glomerulus is surrounded by Bowman's capsule, the beginning component of nephrons in the vertebrate kidney. A glomerulus receives its blood supply from an afferent arteriole of the renal...

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Mutations in the podocin gene NPHS2 can cause nephrotic syndrome, such as Focal Segmental Glomerulosclerosis (FSGS) or Minimal Change Disease

Minimal change disease

Minimal Change Disease is a disease of the kidney that causes nephrotic syndrome and usually affects children .-Epidemiology:...

(MCD).