Propofol
Overview
Propofol is a short-acting, intravenously
administered hypnotic
agent. Its uses include the induction and maintenance of general anesthesia, sedation for mechanically ventilated
adults, and procedural sedation
. Propofol is also commonly used in veterinary medicine
. Propofol is approved for use in more than 50 countries, and generic
versions are available.
Chemically, propofol is unrelated to barbiturate
s and has largely replaced sodium thiopental
(Pentothal) for induction of anesthesia because recovery from propofol is more rapid and "clear" when compared with thiopental.
Intravenous therapy
Intravenous therapy or IV therapy is the infusion of liquid substances directly into a vein. The word intravenous simply means "within a vein". Therapies administered intravenously are often called specialty pharmaceuticals...
administered hypnotic
Hypnotic
Hypnotic drugs are a class of psychoactives whose primary function is to induce sleep and to be used in the treatment of insomnia and in surgical anesthesia...
agent. Its uses include the induction and maintenance of general anesthesia, sedation for mechanically ventilated
Mechanical ventilation
In medicine, mechanical ventilation is a method to mechanically assist or replace spontaneous breathing. This may involve a machine called a ventilator or the breathing may be assisted by a physician, respiratory therapist or other suitable person compressing a bag or set of bellows...
adults, and procedural sedation
Procedural sedation
Procedural sedation and analgesia previously referred to as conscious sedation is defined as "a technique of administering sedatives or dissociative agents with or without analgesics to induce a state that allows the patient to tolerate unpleasant procedures while maintaining cardiorespiratory...
. Propofol is also commonly used in veterinary medicine
Veterinary medicine
Veterinary Medicine is the branch of science that deals with the prevention, diagnosis and treatment of disease, disorder and injury in non-human animals...
. Propofol is approved for use in more than 50 countries, and generic
Generic drug
A generic drug is a drug defined as "a drug product that is comparable to brand/reference listed drug product in dosage form, strength, route of administration, quality and performance characteristics, and intended use." It has also been defined as a term referring to any drug marketed under its...
versions are available.
Chemically, propofol is unrelated to barbiturate
Barbiturate
Barbiturates are drugs that act as central nervous system depressants, and can therefore produce a wide spectrum of effects, from mild sedation to total anesthesia. They are also effective as anxiolytics, as hypnotics, and as anticonvulsants...
s and has largely replaced sodium thiopental
Sodium thiopental
Sodium thiopental, better known as Sodium Pentothal , thiopental, thiopentone sodium, or Trapanal , is a rapid-onset short-acting barbiturate general anaesthetic...
(Pentothal) for induction of anesthesia because recovery from propofol is more rapid and "clear" when compared with thiopental.
Unanswered Questions