Proscaline
Encyclopedia
Proscaline, or 4-propoxy-3,5-DMPEA
is a psychedelic
and hallucinogenic drug, used by some as an entheogen
. It has structural and pharmacodynamic properties similar to the drugs mescaline
and escaline
.
s, and is the 4-propyl
oxy
homologue
of mescaline. The full name of the chemical is 4-propyloxy-3,5-dimethoxy
phenethylamine
.
.
, however its close similarity in structure and effects to mescaline could potentially subject possession and sale of proscaline to prosecution under the Federal Analog Act
.
DMPEA
3,4-Dimethoxyphenethylamine is a chemical compound of the phenethylamine class. It is an analogue of dopamine where the 3- and 4-position hydroxy groups have been replaced with methoxy groups. It is also closely related to mescaline which is 3,4,5-trimethoxyphenethylamine.DMPEA was first...
is a psychedelic
Psychedelic
The term psychedelic is derived from the Greek words ψυχή and δηλοῦν , translating to "soul-manifesting". A psychedelic experience is characterized by the striking perception of aspects of one's mind previously unknown, or by the creative exuberance of the mind liberated from its ostensibly...
and hallucinogenic drug, used by some as an entheogen
Entheogen
An entheogen , in the strict sense, is a psychoactive substance used in a religious, shamanic, or spiritual context. Historically, entheogens were mostly derived from plant sources and have been used in a variety of traditional religious contexts...
. It has structural and pharmacodynamic properties similar to the drugs mescaline
Mescaline
Mescaline or 3,4,5-trimethoxyphenethylamine is a naturally occurring psychedelic alkaloid of the phenethylamine class used mainly as an entheogen....
and escaline
Escaline
Escaline is a psychedelic drug and entheogen of the phenethylamine class of compounds. Escaline was first synthesized and reported in the scientific literature by Benington, et al., in 1954, but was later re-examined in the laboratory of David E. Nichols, who prepared a series of mescaline...
.
Chemistry
Proscaline is in a class of compounds commonly known as phenethylaminePhenethylamine
Phenylethylamine or phenethylamine is a natural monoamine alkaloid, trace amine, and also the name of a class of chemicals with many members well known for psychoactive drug and stimulant effects. Studies suggest that phenylethylamine functions as a neuromodulator or neurotransmitter in the...
s, and is the 4-propyl
Propyl
In organic chemistry, propyl is a three-carbon alkyl substituent with chemical formula -C3H7. It is the substituent form of the alkane propane...
oxy
Oxygen
Oxygen is the element with atomic number 8 and represented by the symbol O. Its name derives from the Greek roots ὀξύς and -γενής , because at the time of naming, it was mistakenly thought that all acids required oxygen in their composition...
homologue
Homologous series
In chemistry, a homologous series is a series of compounds with a similar general formula, possessing similar chemical properties due to the presence of the same functional group, and showing a gradation in physical properties as a result of increase in molecular size and mass...
of mescaline. The full name of the chemical is 4-propyloxy-3,5-dimethoxy
Methoxy
In chemistry , methoxy refers to the functional group consisting of a methyl group bound to oxygen. This alkoxy group has the formula O–CH3.The word is used in organic nomenclature usually to describe an ether...
phenethylamine
Phenethylamine
Phenylethylamine or phenethylamine is a natural monoamine alkaloid, trace amine, and also the name of a class of chemicals with many members well known for psychoactive drug and stimulant effects. Studies suggest that phenylethylamine functions as a neuromodulator or neurotransmitter in the...
.
Pharmacology
The mechanism that produces proscaline’s hallucinogenic and entheogenic effects is unknown, though is most likely attributable to 5HT2A and 5HT2C receptor agonism, among others.Popularity
Proscaline is virtually unknown on the black market. Limited accounts of proscaline can be found in journal articles, and in the book PiHKAL (Phenethylamines i Have Known And Loved)PiHKAL
PiHKAL: A Chemical Love Story is a book by Dr. Alexander Shulgin and Ann Shulgin which was published in 1991. The subject of the work is psychoactive phenethylamine chemical derivatives, notably those that act as psychedelics and/or empathogen-entactogens...
.
Legality
Proscaline is unscheduled and unregulated in the United StatesUnited States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
, however its close similarity in structure and effects to mescaline could potentially subject possession and sale of proscaline to prosecution under the Federal Analog Act
Federal Analog Act
The Federal Analog Act, , is a controversial section of the United States Controlled Substances Act which allowed any chemical "substantially similar" to a controlled substance listed in Schedule I or II to be treated as if it were also listed in those schedules, but only if intended for human...
.