RABEPK
Encyclopedia
Rab9 effector protein with Kelch motifs also known as p40 is a protein
that in humans is encoded by the RABEPK gene
.
Membrane-associated p40, in together with RAB9A
, facilitates the transport of the mannose 6-phosphate receptor (MPR
) from endosome
s to the trans-Golgi network
.
with RAB9A
and FYVE finger-containing phosphoinositide kinase.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the RABEPK gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Membrane-associated p40, in together with RAB9A
RAB9A
Ras-related protein Rab-9A is a protein that in humans is encoded by the RAB9A gene.-Interactions:RAB9A has been shown to interact with RABEPK and TIP47.-Further reading:...
, facilitates the transport of the mannose 6-phosphate receptor (MPR
Mannose 6-phosphate receptor
In the fields of biochemistry and cell biology, mannose 6-phosphate receptors are proteins that bind newly synthesized lysosomal hydrolases in the trans-Golgi network and deliver them to pre-lysosomal compartments. There are two different MPRs, one of ~300kDa and a smaller, dimeric receptor of...
) from endosome
Endosome
In biology, an endosome is a membrane-bound compartment inside eukaryotic cells. It is a compartment of the endocytic membrane transport pathway from the plasma membrane to the lysosome. Molecules internalized from the plasma membrane can follow this pathway all the way to lysosomes for...
s to the trans-Golgi network
Golgi apparatus
The Golgi apparatus is an organelle found in most eukaryotic cells. It was identified in 1898 by the Italian physician Camillo Golgi, after whom the Golgi apparatus is named....
.
Interactions
RABEPK has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with RAB9A
RAB9A
Ras-related protein Rab-9A is a protein that in humans is encoded by the RAB9A gene.-Interactions:RAB9A has been shown to interact with RABEPK and TIP47.-Further reading:...
and FYVE finger-containing phosphoinositide kinase.