Ras-related protein Rap-1A is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the RAP1A gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

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Function

The product of this gene belongs to the family of Ras-related protein

Rap GTP-binding protein

Rap GTP-binding protein also known as Ras-related proteins or simply RAP is a type of small GTPase, similar in structure to Ras.These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common...

s. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.

Interactions

RAP1A has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with C-Raf

C-Raf

RAF proto-oncogene serine/threonine-protein kinase also known as proto-oncogene c-RAF or simply c-Raf is an enzyme that in humans is encoded by the RAF1 gene. The c-Raf protein functions in the MAPK/ERK signal transduction pathway as part of a protein kinase cascade...

, PDE6D

PDE6D

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene.-Interactions:...

, TSC2

TSC2

Tuberous sclerosis protein 2, also known as TSC2 and Tuberin, is a human protein and gene.-Interactions:TSC2 has been shown to interact with FOXO1, GSK3B, Peptidylglycine alpha-amidating monooxygenase, RAP1A, MAPK1, AKT1, AXIN1, TSC1, PTK2, Protein kinase, AMP-activated, alpha 1, YWHAZ, RPS6KA1,...

, RALGDS

RALGDS

Ral guanine nucleotide dissociation stimulator is a protein that in humans is encoded by the RALGDS gene.-Interactions:RALGDS has been shown to interact with RRAS, RAP2A, RAP1A, KRAS, RAPGEF2, MRAS, HRAS, Arrestin beta 2 and Arrestin beta 1....

, RAPGEF2

RAPGEF2

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.-Interactions:RAPGEF2 has been shown to interact with RAP1A and RALGDS.-Further reading:...

 and MLLT4

MLLT4

Afadin is a protein that in humans is encoded by the MLLT4 gene.-Interactions:MLLT4 has been shown to interact with F11 receptor, RAP1A, LMO2, EPHB3, RAP1GAP, PVRL1, PVRL3, USP9X, SORBS1, BCR gene, Tight junction protein 1, Profilin 1, HRAS and SSX2IP.-Further reading:...

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