RAR-related orphan receptor alpha (ROR-alpha), also known as NR1F1 (nuclear receptor subfamily 1, group F, member 1) is a nuclear receptor

Nuclear receptor

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules...

 that in humans is encoded by the RORA gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Function

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2

NME2

Nucleoside diphosphate kinase B is an enzyme that in humans is encoded by the NME2 gene.-Interactions:NME2 has been shown to interact with NME3 and HERC5.-Further reading:...

, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1

NME1

Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene. It is thought to be a metastasis suppressor.-Interactions:...

, the product of a tumor metastasis suppressor

Metastasis suppressor

A metastasis suppressor is a protein that acts to slow or prevent metastases from spreading in the body of an organism with cancer. Metastasis is one of the most lethal attributes of cancer. This attribute is responsible for about ninety percent of human cancer deaths...

 candidate gene. Four transcript variants encoding different isoforms have been described for this gene.

Interactions

RAR-related orphan receptor alpha has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with EP300

EP300

E1A binding protein p300 also known as EP300 or p300 is a protein that, in humans, is encoded by the EP300 gene. This protein regulates the activity of many genes in tissues throughout the body...

 and NME1

NME1

Nucleoside diphosphate kinase A is an enzyme that in humans is encoded by the NME1 gene. It is thought to be a metastasis suppressor.-Interactions:...

.