RGM domain family, member B, also known as RGMB, is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the RGMB gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

.

Function

RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule

Repulsive guidance molecule

Repulsive Guidance Molecules are members of a three gene family composed of RGMa, RGMb, and RGMc ....

 family (see also RGMA

RGMA

Repulsive guidance molecule A also known as RGMa is a protein that in humans is encoded by the RGMA gene.- Function :RGMa is a repulsive guidance molecule for retinal axons. Furthermore neogenin functions as a receptor for RGM. Neogenin overexpression and RGM downexpression in the developing...

 and RGMC

Hemojuvelin

Hemojuvelin is a membrane-bound and soluble protein in mammals that is responsible for the iron overload condition known as juvenile hemochromatosis in humans, a severe form of hemochromatosis. In humans, the hemojuvelin protein is encoded by the HFE2 gene...

) and contributes to the patterning of the developing nervous system. A 2010 publication by Severyn and Rotwein demonstrated that the RGMb homologue RGMc/HJV, is transcriptionally regulated during muscle differentiation. Future work will need to determine how RGMb is regulated in neuronal tissue.