RPA2
Encyclopedia
Replication protein A 32 kDa subunit is a protein
that in humans is encoded by the RPA2 gene
.
with Ku70, Replication protein A1, RPA3
, DNA-PKcs, STAT3
, Cyclin O
, MEN1
, TP53BP1
and Uracil-DNA glycosylase
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the RPA2 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
RPA2 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Ku70, Replication protein A1, RPA3
RPA3
Replication protein A 14 kDa subunit is a protein that in humans is encoded by the RPA3 gene.-Interactions:RPA3 has been shown to interact with Replication protein A1 and RPA2.-Further reading:...
, DNA-PKcs, STAT3
STAT3
Signal transducer and activator of transcription 3 also known as STAT3 is a transcription factor which in humans is encoded by the STAT3 gene.- Function :The protein encoded by this gene is a member of the STAT protein family...
, Cyclin O
Cyclin O
Cyclin-O is a protein that in humans is encoded by the CCNO gene.-Interactions:Cyclin O has been shown to interact with RPA2 and PCNA.-Further reading:...
, MEN1
MEN1
Menin is a protein that in humans is encoded by the MEN1 gene. Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1....
, TP53BP1
TP53BP1
Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene.- Clinical significance :53BP1 is underexpressed in most cases of triple-negative breast cancer....
and Uracil-DNA glycosylase
Uracil-DNA glycosylase
Uracil-DNA glycosylase, also known as UNG or UDG, is a human gene though orthologs exist ubiquitously among prokaryotes and eukaryotes and even in some DNA viruses. The first uracil DNA-glycosylase was isolated from Escherichia coli....
.