RTI-352
Encyclopedia
RTI-352 is a phenyltropane
that is used as a radiolabeling ligand for the DAT.
RTI-352 has been configured to have 1R,2S,3R stereochemistry and is therefore a geometric isomer of β-CIT.
Based on X-ray crystallography, this compound is in a tautomer
ic equilibrium residing mostly on the side of the boat-shaped conformer.
Die synthesis runs as follows:
Phenyltropane
Phenyltropanes were originally developed to reduce cocaine addiction and dependency. In general these compounds act as inhibitors of the plasmalemmal monoamine reuptake transporters. Although RTI holds a strong position in this field, they are not the only researchers that have prepared these...
that is used as a radiolabeling ligand for the DAT.
RTI-352 has been configured to have 1R,2S,3R stereochemistry and is therefore a geometric isomer of β-CIT.
Based on X-ray crystallography, this compound is in a tautomer
Tautomer
Tautomers are isomers of organic compounds that readily interconvert by a chemical reaction called tautomerization. This reaction commonly results in the formal migration of a hydrogen atom or proton, accompanied by a switch of a single bond and adjacent double bond...
ic equilibrium residing mostly on the side of the boat-shaped conformer.
Die synthesis runs as follows: