Ravi Iyengar, Ph.D., is a systems biologist

Systems biology

Systems biology is a term used to describe a number of trends in bioscience research, and a movement which draws on those trends. Proponents describe systems biology as a biology-based inter-disciplinary study field that focuses on complex interactions in biological systems, claiming that it uses...

 and Director of the Experimental Therapeutics Institute at the Mount Sinai School of Medicine

Mount Sinai School of Medicine

Mount Sinai School of Medicine is an American medical school in the borough of Manhattan in New York City, currently ranked among the top 20 medical schools in the United States. It was chartered by Mount Sinai Hospital in 1963....

 in New York City

New York City

New York is the most populous city in the United States and the center of the New York Metropolitan Area, one of the most populous metropolitan areas in the world. New York exerts a significant impact upon global commerce, finance, media, art, fashion, research, technology, education, and...

, as well as the Dorothy H. and Lewis Rosenstiel Professor and Chairman of the Department of Pharmacology and Systems Therapeutics and Director and Principal Investigator of the NIGMS

National Institute of General Medical Sciences

The National Institute of General Medical Sciences is a part of the National Institutes of Health that primarily supports research that lays the foundation for advances in disease diagnosis, treatment and prevention...

-funded Systems Biology Center New York at The Mount Sinai Medical Center

Mount Sinai Hospital, New York

Mount Sinai Hospital, founded in 1852, is one of the oldest and largest teaching hospitals in the United States. In 2011-2012, Mount Sinai Hospital was ranked as one of America's best hospitals by U.S...

.

Trained as a biochemist

Biochemist

Biochemists are scientists who are trained in biochemistry. Typical biochemists study chemical processes and chemical transformations in living organisms. The prefix of "bio" in "biochemist" can be understood as a fusion of "biological chemist."-Role:...

, Iyengar studies cellular signaling

Cell signaling

Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as normal tissue...

 networks using both experiments and computer simulations. His laboratory focuses on how cell signals are routed and processed through cellular signaling networks within cells to discover new drug targets for complex diseases. He has published more than 100 primary papers, 92 reviews and is the editor of 6 books.

Biography

Iyengar earned both an undergraduate degree in Chemistry and Physics in 1971 and a master's degree in Biophysics

Biophysics

Biophysics is an interdisciplinary science that uses the methods of physical science to study biological systems. Studies included under the branches of biophysics span all levels of biological organization, from the molecular scale to whole organisms and ecosystems...

 in 1973 from the University of Mumbai

University of Mumbai

The University of Mumbai , is a state university located in Mumbai, Maharashtra, India. It was known as the University of Bombay until 1996 when the city of Bombay was renamed as Mumbai. The affiliated colleges of the university are spread throughout the city of Mumbai and four coastal districts in...

 in India

India

India , officially the Republic of India , is a country in South Asia. It is the seventh-largest country by geographical area, the second-most populous country with over 1.2 billion people, and the most populous democracy in the world...

. He completed his Ph.D. in Biophysical Sciences at the University of Houston

University of Houston

The University of Houston is a state research university, and is the flagship institution of the University of Houston System. Founded in 1927, it is Texas's third-largest university with nearly 40,000 students. Its campus spans 667 acres in southeast Houston, and was known as University of...

 in 1977. He joined Baylor College of Medicine

Baylor College of Medicine

Baylor College of Medicine, located in the Texas Medical Center in Houston, Texas, USA, is a highly regarded medical school and leading center for biomedical research and clinical care...

 in 1977 as a postdoctoral fellow and rose to Assistant and then Associate Professor. In 1986, he joined the Department of Pharmacology at The Mount Sinai Medical Center as an Associate Professor. In 1999, he was appointed Chairman of the Department of Pharmacology at Mount Sinai, and in 2001 he was named Mount Sinai's Dorothy H. and Lewis Rosenstiel Professor and Chair of the Department of Pharmacology and Biological Chemistry.

Iyengar served as the Dean of Research for The Mount Sinai School of Medicine from 2002 to 2004.

In 2004, Iyengar was elected fellow of the American Association for the Advancement of Science

American Association for the Advancement of Science

The American Association for the Advancement of Science is an international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting scientific education and science outreach for the...

. Additional honors include:

• Established Investigator, American Heart Association
  American Heart Association
  The American Heart Association is a non-profit organization in the United States that fosters appropriate cardiac care in an effort to reduce disability and deaths caused by cardiovascular disease and stroke. It is headquartered in Dallas, Texas...
  
  , 1980–1983
• New Investigator Award, NIH
  National Institutes of Health
  The National Institutes of Health are an agency of the United States Department of Health and Human Services and are the primary agency of the United States government responsible for biomedical and health-related research. Its science and engineering counterpart is the National Science Foundation...
  
  , 1978–1980
• National Research Service Award, NIH

Iyengar holds Patent No. 20080261820: Methods to Analyze Biological Networks.

Research grants

• Structure and Function of Signal Transducing Components, 5R01DK03876-21, National Institute of Diabetes and Digestive and Kidney Diseases
  National Institute of Diabetes and Digestive and Kidney Diseases
  The National Institute of Diabetes and Digestive and Kidney Diseases , of the U.S. National Institutes of Health, conducts and supports research on many of the most serious diseases affecting public health...
  
  
• Dynamics Underlying Tissue Integrity, 1R01DK087650-01, National Institute of Diabetes and Digestive Diseases and Kidney Diseases

• Systems Biology Center in New York, 5P50GM071558-03, National Institute of General Medical Sciences

• Functions of Regulatory Motifs in Signaling Networks, 5R01GM054508-21, National Institute of General Medical Sciences

• Modeling Cell Regulatory Networks, 5R01GM072853-04, National Institute of General Medical Sciences

Books

• Heterotrimeric G Proteins, Volume 237 (Methods in Enzymology). John N. Abelson, Melvin I. Simon, Ravi Iyengar, editors. Academic Press; 1st edition (June 28, 1994) ISBN 0121821382
• Heterotrimeric G-Protein Effectors, Volume 238 (Methods in Enymology). John N. Abelson, Melvin I. Simon, Ravi Iyengar, Editors. Academic Press; 1st Edition (September 1994) ISBN 0121821390
• G Protein Pathways, Part A: Receptors, Volume 343 (Methods in Enymology). Ravi Iyengar, John D. Hildebrandt, Editors. Academic Press; 1st Edition (October 2001) ISBN 0121822443
• G Protein Pathways, Part B: G Proteins and Their Regulators, Volume 344 (Methods in Enzymology). Ravi Iyengar, John D. Hildebrandt, Editors. Academic Press; 1st Edition (December 2001) ISBN 0121822451
• G Protein Pathways, Part C: Effector Mechanisms, Volume 345 (Methods in Enzymology). Ravi Ravi Iyengar, John D. Hildebrandt, Editors. Academic Press; 1st Edition (October 2001) ISBN 012182246X

Publications

Partial list:

• Ram PT, Horvath CM, Iyengar R. Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein. Science. 7 January 2000;287(5450):142-4. PMID 10615050
• Jordan JD, Landau EM, Iyengar R. Signaling networks: the origins of cellular multitasking. Cell. 13 October 2000;103(2):193-200. PMID 11057893
• Bhalla US, Ram PT, Iyengar R. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science. 9 August 2002;297(5583):1018-23. PMID 12169734
• Jordan JD, He JC, Eungdamrong NJ, Gomes I, Ali W, Nguyen T, Bivona TG, Philips MR, Devi LA, Iyengar R. Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. J Biol Chem. 25 March 2005;280(12):11413-21. PMID 15657046
• Ma'ayan A, Blitzer RD, Iyengar R. Toward predictive models of mammalian cells. Annu Rev Biophys Biomol Struct. 2005;34:319-49. PMID 15869393
• Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R. Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science. 12 August 2005;309(5737):1078-83. PMID 16099987
• Moriarty TM, Sealfon SC
  Stuart C. Sealfon
  Stuart C. Sealfon, M.D., is an American neurologist who studies the mechanisms of both the therapeutic and adverse effects of drugs. He was an early adopter of the use of massively parallel qPCR and fluorescent in situ hybridization to characterize cell response state and his research...
  
  , Carty CJ, Roberts JL, Iyengar R, Landau EM. Coupling of exogenous receptors to phospholipase C in Xenopus oocytes through pertussis toxin sensitive and insensitive pathways. J. Biol. Chem. 264:13524-13530, 1989. PMID 2474532
• Eungdamrong NJ, Iyengar R. Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi. Biophys J. 1 February 2007;92(3):808-15. PMID 17098795
• Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat Cell Biol. 2007 Aug;9(8):858-67. Nat Cell Biol. 2007 Aug;9(8):858-67. PMID 17671451
• Lipshtat A, Purushothaman SP, Iyengar R, Ma'ayan A. Functions of bifans in context of multiple regulatory motifs in signaling networks. Biophys J. 1 April 2008;94(7):2566-79. PMID 18178648
• Bromberg KD, Ma'ayan A, Neves SR, Iyengar R. Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science. 16 May 2008;320(5878):903-9. PMID 18487186
• Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R. Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell. 16 May 2008;133(4):666-80. PMID 18485874
• Bhalla US, Iyengar R. Emergent properties of networks of biological signaling pathways. Science. 15 January 1999;283(5400):381-7. PMID 9888852
• Weng G, Bhalla US, Iyengar R. Complexity in biological signaling systems. Science. 2 April 1999;284(5411):92-6. PMID 10102825
• Jordan JD, Carey KD, Stork PJ, Iyengar R. Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein. J Biol Chem. 30 July 1999;274(31):21507-10. PMID 10419452
• Ram PT, Horvath CM, Iyengar R. Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein. Science. 7 January 2000;287(5450):142-4. PMID 10615050
• Lipshtat A, Jayaraman G, He JC, Iyengar R. Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues. Proc Natl Acad Sci U S A. 28 December 2009. PMID 20080566
• Berger SI, Iyengar R. Role of systems pharmacology in understanding drug adverse events. Wiley Interdiscip Rev Syst Biol Med. 2011 Mar-Apr;3(2):129-35. PMID 20803507
• Rangamani P, Fardin MA, Xiong Y, Lipshtat A, Rossier O, Sheetz MP, Iyengar R. Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading. Biophys J. 2011 Feb 16;100(4):845-57. PMID 21320428
• Xiong Y, Rangamani P, Fardin MA, Lipshtat A, Dubin-Thaler B, Rossier O, Sheetz MP, Iyengar R. Mechanisms controlling cell size and shape during isotropic cell-spreading. Biophys J. 2010 May 19;98(10):2136-46. PMID 20483321
• Berger SI, Ma'ayan A, Iyengar R. Systems pharmacology of arrhythmias. Sci Signal. 2010 Apr 20;3(118):ra30. PMID 20407125
• Zorina Y, Iyengar R, Bromberg KD. Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth. J Biol Chem. 2010 Jan 8;285(2):1358-70. PMID 19861414
• Lipshtat A, Jayaraman G, He JC, Iyengar R. Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues. Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1247-52. PMID 20080566
• Berger SI, Iyengar R. Network analyses in systems pharmacology. Bioinformatics. 2009 Oct 1;25(19):2466-72. PMID 19648136
• Neves SR, Iyengar R. Models of spatially restricted biochemical reaction systems. J Biol Chem. 2009 Feb 27;284(9):5445-9. PMID 18940805
• Ma'ayan A, Cecchi GA, Wagner J, Rao AR, Iyengar R, Stolovitzky G. Ordered cyclic motifs contribute to dynamic stability in biological and engineered networks. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19235-40. PMID 19033453
• Bromberg KD, Ma'ayan A, Neves SR, Iyengar R. Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science 2008;320(5878):903-9. PMID 18487186
• Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R. Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell 2008;133(4):666-80. PMID 18485874
• Lipshtat A, Purushothaman SP, Iyengar R, Ma'ayan A. Functions of bifans in context of multiple regulatory motifs in signaling networks. Biophys J. 2008 Apr 1;94(7):2566-79. PMID 18178648
• Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat Cell Biol. 2007 Aug;9(8):858-67. PMID 17671451
• Ma'ayan A, Jenkins SL, Goldfarb J, Iyengar R. Network analysis of FDA approved drugs and their targets. Mt Sinai J Med. 2007 Apr;74(1):27-32. PMID 17516560
• Eungdamrong NJ, Iyengar R. Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi. Biophys J. 2007 Feb 1;92(3):808-15. PMID 17098795
• Ma'ayan A, Lipshtat A, Iyengar R. Topology of resultant networks shaped by evolutionary pressure. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jun;73(6 Pt 1):061912. PMID 16906869
• Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R. Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science. 2005 Aug 12;309(5737):1078-83. PMID 16099987
• Ma'ayan A, Blitzer RD, Iyengar R. Toward predictive models of mammalian cells. Annu Rev Biophys Biomol Struct. 2005;34:319-49. PMID 15869393
• Jordan JD, He JC, Eungdamrong NJ, Gomes I, Ali W, Nguyen T, Bivona TG, Philips MR, Devi LA, Iyengar R. Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. J Biol Chem. 2005 Mar 25;280(12):11413-21. PMID 15657046
• Neves SR, Ram PT, Iyengar R. G protein pathways. Science. 2002 May 31;296(5573):1636-9. PMID 12040175

External links

• The Mount Sinai Hospital homepage
• The Mount Sinai School of Medicine homepage
• Laboratories and Programs/Iyengar Laboratory at The Mount Sinai Medical Center
• Systems Biology Center New York
• The Experimental Therapeutics Institute at The Mount Sinai School of Medicine