Recaldent, with the technical name casein phosphopeptide – amorphous calcium phosphate, or CPP-ACP, is a milk derived product that strengthens and remineralizes teeth and helps prevent dental caries (tooth decay). Casein phosphopeptides (CPP) from the major protein of milk have the remarkable ability to stabilize calcium, phosphate and fluoride ions as water soluble amorphous complexes that provide bioavailable calcium, phosphate and fluoride ions to the tooth. These complexes of amorphous calcium phosphate and amorphous calcium fluoride phosphate stabilized by the CPP have been demonstrated in a range of laboratory, animal and short-term human clinical trials to repair (remineralise) early stages of tooth decay by replacing the calcium and phosphate ions lost due to decay. Three longer-term, randomized, controlled clinical trials (RCTs) have demonstrated the efficacy of CPP-ACP in slowing the progression of dental caries and in regressing (repairing) early stages of tooth decay. Another RCT showed that CPP and calcium carbonate in a toothpaste formulation, which would spontaneously form CPP-ACP in saliva, significantly reduced caries experience in children compared with a placebo toothpaste. A systematic review with meta-analysis by Yengopal and Mickenautsch concluded that “the results of the clinical in situ trials indicate a short-term remineralization effect of CPP-ACP. Additionally, the promising in vivo RCT results suggest a caries-preventing effect for long-term clinical CPP-ACP use”. Recaldent (CPP-ACP) can be delivered to the teeth by sugar-free gum (Trident XtraCare with Recaldent), professional tooth crème (GC's Tooth Mousse, MI Paste and MI Paste Plus) and dairy milk (Meiji Milk de Recaldent).