Reticuline is a chemical compound that can be found in Lindera aggregata

Lindera aggregata

Lindera aggregata is a plant species belonging to the Lindera genus.-Other names:Engl.: evergreen lindera, Japanese evergreen spicebush.TCM: trad.烏樂, simpl. 乌药 or 乌乐, pinyin : wūyào....

. It is also one of the alkaloid

Alkaloid

Alkaloids are a group of naturally occurring chemical compounds that contain mostly basic nitrogen atoms. This group also includes some related compounds with neutral and even weakly acidic properties. Also some synthetic compounds of similar structure are attributed to alkaloids...

s found in opium

Opium

Opium is the dried latex obtained from the opium poppy . Opium contains up to 12% morphine, an alkaloid, which is frequently processed chemically to produce heroin for the illegal drug trade. The latex also includes codeine and non-narcotic alkaloids such as papaverine, thebaine and noscapine...

.

Metabolism

3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase

3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase

In enzymology, a 3'-hydroxy-N-methyl--coclaurine 4'-O-methyltransferase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are S-adenosyl methionine and 3'-hydroxy-N-methyl--coclaurine, whereas its two products are S-adenosylhomocysteine and -reticuline.This...

 uses S-adenosyl methionine

S-Adenosyl methionine

S-Adenosyl methionine is a common cosubstrate involved in methyl group transfers. SAM was first discovered in Italy by G. L. Cantoni in 1952. It is made from adenosine triphosphate and methionine by methionine adenosyltransferase . Transmethylation, transsulfuration, and aminopropylation are the...

 and 3'-hydroxy-N-methyl-(S)-coclaurine to produce S-adenosylhomocysteine and (S)-reticuline.

Reticuline oxidase

Reticuline oxidase

In enzymology, a reticuline oxidase is an enzyme that catalyzes the chemical reaction-reticuline + O2 \rightleftharpoons -scoulerine + H2O2...

 uses (S)-reticuline and O₂ to produce (S)-scoulerine

Scoulerine

Scoulerine, also known as discretamine and aequaline, is an alkaloid found in the Opium poppy, Croton flavens, and certain plants in the Erythrina genus. Studies show that scoulerine is an antagonist at the α2-adrenoceptor, α1D-adrenoceptor and 5-HT receptor. It has also been found to be a GABAA...

 and H₂O₂.

Salutaridine synthase

Salutaridine synthase

In enzymology, a salutaridine synthase is an enzyme that catalyzes the chemical reaction-reticuline + NADPH + H+ + O2 \rightleftharpoons salutaridine + NADP+ + 2 H2O...

 uses (R)-reticuline, NADPH, H⁺, and O₂ to produce salutaridine

Salutaridine

Salutaridine is an alkaloid that is present in the morphinian alkaloid pathway of opium poppy. Its precursor is the alkaloid -reticuline. -reticuline is converted to salutaridine by the enzyme salutaridine synthase. Salutaridine is converted to salutaridinol by the enzyme salutaridine reductase ,...

, NADP⁺, and H₂O.

1,2-dehydroreticulinium reductase (NADPH)

1,2-dehydroreticulinium reductase (NADPH)

In enzymology, a 1,2-dehydroreticulinium reductase is an enzyme that catalyzes the chemical reaction-reticuline + NADP+ \rightleftharpoons 1,2-dehydroreticulinium + NADPH + H+...

 uses (R)-reticuline and NADP⁺ to produce 1,2-dehydroreticulinium, NADPH, and H⁺.