Reversible inhibitor
Encyclopedia
For acetylcholine esterase (AChE), reversible inhibitors are those that do not irreversibly bond to and decactivate AChE.
Drugs that reversibly inhibit acetylcholine esterase are currently being explored as treatments for Alzheimer's disease
and myasthenia gravis
, among others. Examples include tacrine
and aricept.
Drugs that reversibly inhibit acetylcholine esterase are currently being explored as treatments for Alzheimer's disease
Alzheimer's disease
Alzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death...
and myasthenia gravis
Myasthenia gravis
Myasthenia gravis is an autoimmune neuromuscular disease leading to fluctuating muscle weakness and fatiguability...
, among others. Examples include tacrine
Tacrine
Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist . It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease, and was marketed under the trade name Cognex. Tacrine was first synthesised by Adrien Albert at the...
and aricept.