The CyaR RNA non-coding RNA

Non-coding RNA

A non-coding RNA is a functional RNA molecule that is not translated into a protein. Less-frequently used synonyms are non-protein-coding RNA , non-messenger RNA and functional RNA . The term small RNA is often used for short bacterial ncRNAs...

 was identified in a large scale screen of E. coli and was called candidate 14. The exact 5' and 3' ends of this RNA are uncertain. This gene lies between yegQ and orgK in E. coli. This small RNA was shown to be bound by the Hfq protein

Hfq protein

The Hfq protein encoded by the hfq gene was discovered in 1968 as an Escherichia. coli host factor that was essential for replication of the bacteriophage Qβ. It is now clear that Hfq is an abundant bacterial RNA binding protein which has many important physiological roles. Usually mediated by...

. This RNA has been renamed as CyaR for (cyclic AMP-activated
RNA). It has recently been shown that CyaR RNA acts as a repressor of the porin

Porin

Porin may refer to:* Porin , a transmembrane protein* Porin , a Croatian grand Opera, first performed in 1897* Porin , the Croatian national music industry award, first awarded in 1994 and named after the opera...

 OmpX. It has also been shown that cyaR expression is tightly controlled by the cyclic AMP receptor protein, CRP

CRP

-Biochemistry and medicine:* C-reactive protein , an acute phase protein produced by the liver* cAMP receptor protein is a regulatory protein in bacteria* Collagen-related peptides...

.