SAGE KE
Encyclopedia
The Science of Aging Knowledge Environment (SAGE KE) was an online
scientific
resource provided by the American Association for the Advancement of Science
(AAAS).
with Stanford University
Libraries and The Center for Resource Economics/Island Press (Island Press) in 1996 to find means to utilize internet
-based technologies to enhance access to scientific information and improve the effectiveness of information transfer. The collaborative coined the term Knowledge Environment (KE) to describe the collection of electronic networking
tools they were seeking to develop.
SAGE KE is the third in a series of Knowledge Environments developed by Science and AAAS
, after the Signal Transduction
Knowledge Environment (STKE) and AIDScience. Funding for SAGE KE comes from The Ellison Medical Foundation, founded and supported by Oracle Corporation
CEO Larry Ellison
.
SAGE KE published its final issue on 28 June 2006 due to lack of funding. The interactive content was discontinued during the Summer of 2006, leaving the SAGE KE site as an archive by August 2006.
s through the internet
, to provide searchable database
s of information on aging and to provide an active environment in which biogerontologists
could share and debate their understandings.
community weblog devoted to research in the biology of aging
. It was established in July 2006 in reaction to the termination of the SAGE KE. The primary mission of the site is to provide timely commentary and review of recently published articles in the scholarly literature, either directly or indirectly related to aging. Articles on the site discuss a range of scientific topics, including Alzheimer's disease
, bioinformatics
, calorie restriction
, regulation of gene expression
, the role of mitochondria in the aging process, and evolution
ary theories of aging.
ONLINE
ONLINE is a magazine for information systems first published in 1977. The publisher Online, Inc. was founded the year before. In May 2002, Information Today, Inc. acquired the assets of Online Inc....
scientific
Science
Science is a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe...
resource provided by the American Association for the Advancement of Science
American Association for the Advancement of Science
The American Association for the Advancement of Science is an international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting scientific education and science outreach for the...
(AAAS).
History and Organization
The American Association for the Advancement of Science established a collaborationCollaboration
Collaboration is working together to achieve a goal. It is a recursive process where two or more people or organizations work together to realize shared goals, — for example, an intriguing endeavor that is creative in nature—by sharing...
with Stanford University
Stanford University
The Leland Stanford Junior University, commonly referred to as Stanford University or Stanford, is a private research university on an campus located near Palo Alto, California. It is situated in the northwestern Santa Clara Valley on the San Francisco Peninsula, approximately northwest of San...
Libraries and The Center for Resource Economics/Island Press (Island Press) in 1996 to find means to utilize internet
Internet
The Internet is a global system of interconnected computer networks that use the standard Internet protocol suite to serve billions of users worldwide...
-based technologies to enhance access to scientific information and improve the effectiveness of information transfer. The collaborative coined the term Knowledge Environment (KE) to describe the collection of electronic networking
Computer network
A computer network, often simply referred to as a network, is a collection of hardware components and computers interconnected by communication channels that allow sharing of resources and information....
tools they were seeking to develop.
SAGE KE is the third in a series of Knowledge Environments developed by Science and AAAS
American Association for the Advancement of Science
The American Association for the Advancement of Science is an international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting scientific education and science outreach for the...
, after the Signal Transduction
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a cell surface receptor. In turn, this receptor alters intracellular molecules creating a response...
Knowledge Environment (STKE) and AIDScience. Funding for SAGE KE comes from The Ellison Medical Foundation, founded and supported by Oracle Corporation
Oracle Corporation
Oracle Corporation is an American multinational computer technology corporation that specializes in developing and marketing hardware systems and enterprise software products – particularly database management systems...
CEO Larry Ellison
Larry Ellison
Lawrence Joseph "Larry" Ellison is the co-founder and chief executive officer of Oracle Corporation, one of the world's leading enterprise software companies. As of 2011, he is the third wealthiest American citizen, with an estimated worth of $33 billion.- Early life :Larry Ellison was born in the...
.
SAGE KE published its final issue on 28 June 2006 due to lack of funding. The interactive content was discontinued during the Summer of 2006, leaving the SAGE KE site as an archive by August 2006.
Activities
The focus of SAGE KE was to provide timely access to information about advances on basic mechanisms of aging and age-related diseaseDisease
A disease is an abnormal condition affecting the body of an organism. It is often construed to be a medical condition associated with specific symptoms and signs. It may be caused by external factors, such as infectious disease, or it may be caused by internal dysfunctions, such as autoimmune...
s through the internet
Internet
The Internet is a global system of interconnected computer networks that use the standard Internet protocol suite to serve billions of users worldwide...
, to provide searchable database
Database
A database is an organized collection of data for one or more purposes, usually in digital form. The data are typically organized to model relevant aspects of reality , in a way that supports processes requiring this information...
s of information on aging and to provide an active environment in which biogerontologists
Gerontology
Gerontology is the study of the social, psychological and biological aspects of aging...
could share and debate their understandings.
Ouroboros
Ouroboros is a WordPressWordPress
WordPress is a free and open source blogging tool and publishing platform powered by PHP and MySQL. It is often customized into a content management system . It has many features including a plug-in architecture and a template system. WordPress is used by over 14.7% of Alexa Internet's "top 1...
community weblog devoted to research in the biology of aging
Senescence
Senescence or biological aging is the change in the biology of an organism as it ages after its maturity. Such changes range from those affecting its cells and their function to those affecting the whole organism...
. It was established in July 2006 in reaction to the termination of the SAGE KE. The primary mission of the site is to provide timely commentary and review of recently published articles in the scholarly literature, either directly or indirectly related to aging. Articles on the site discuss a range of scientific topics, including Alzheimer's disease
Alzheimer's disease
Alzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death...
, bioinformatics
Bioinformatics
Bioinformatics is the application of computer science and information technology to the field of biology and medicine. Bioinformatics deals with algorithms, databases and information systems, web technologies, artificial intelligence and soft computing, information and computation theory, software...
, calorie restriction
Calorie restriction
Caloric restriction , or calorie restriction, is a dietary regimen that restricts calorie intake, where the baseline for the restriction varies, usually being the previous, unrestricted, intake of the subjects...
, regulation of gene expression
Gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. These products are often proteins, but in non-protein coding genes such as ribosomal RNA , transfer RNA or small nuclear RNA genes, the product is a functional RNA...
, the role of mitochondria in the aging process, and evolution
Evolution
Evolution is any change across successive generations in the heritable characteristics of biological populations. Evolutionary processes give rise to diversity at every level of biological organisation, including species, individual organisms and molecules such as DNA and proteins.Life on Earth...
ary theories of aging.
See also
- AgeingAgeingAgeing or aging is the accumulation of changes in a person over time. Ageing in humans refers to a multidimensional process of physical, psychological, and social change. Some dimensions of ageing grow and expand over time, while others decline...
- American Association for the Advancement of ScienceAmerican Association for the Advancement of ScienceThe American Association for the Advancement of Science is an international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting scientific education and science outreach for the...
- American Aging AssociationAmerican Aging AssociationThe American Aging Association is a non-profit, tax-exempt biogerontology organization of scientists and laypeople dedicated to biomedical aging studies intended to slow the aging process. The abbreviation AGE is intended to be representative of the organization, even though it is not an acronym...
- BiogerontologyGerontologyGerontology is the study of the social, psychological and biological aspects of aging...
- ScienceScience (journal)Science is the academic journal of the American Association for the Advancement of Science and is one of the world's top scientific journals....
- SenescenceSenescenceSenescence or biological aging is the change in the biology of an organism as it ages after its maturity. Such changes range from those affecting its cells and their function to those affecting the whole organism...