SB-408,124
Encyclopedia
SB-408,124 is a drug which is a non-peptide antagonist selective for the orexin receptor
subtype OX1
, with around 70x selectivity for OX1 over OX2
receptors, and improved oral bioavailability compared to the older OX1 antagonist SB-334,867
. It is used in scientific research into the function of orexinergic neurons in the body.
Orexin receptor
The orexin receptor is a G-protein-coupled receptor that binds the neuropeptide hormone orexin. There are two variants, OX1 and OX2, each encoded by a different gene .-External links:...
subtype OX1
Hypocretin (orexin) receptor 1
Orexin receptor type 1 , also known as hypocretin receptor type 1, is a protein that in humans is encoded by the HCRTR1 gene.- Function :...
, with around 70x selectivity for OX1 over OX2
Hypocretin (orexin) receptor 2
Orexin receptor type 2 , also known as hypocretin receptor type 2, is a protein that in humans is encoded by the HCRTR2 gene.- Function :...
receptors, and improved oral bioavailability compared to the older OX1 antagonist SB-334,867
SB-334,867
SB-334,867 is a drug which was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX1, with around 50x selectivity for OX1 over OX2 receptors...
. It is used in scientific research into the function of orexinergic neurons in the body.