SCN5A
Encyclopedia
The Nav1.5 is a sodium ion channel
protein
that in humans is encoded by the SCN5A gene. Mutations in the gene are associated with long QT syndrome
type 3 (LQT3), Brugada syndrome
, primary cardiac conduction disease and idiopathic ventricular fibrillation
.
with Syntrophin, alpha 1.
Nav1.5 interacts with ankyrin-G through a nine-amino acid ankyrin-G binding sequence.
Sodium ion channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e...
protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SCN5A gene. Mutations in the gene are associated with long QT syndrome
Long QT syndrome
The long QT syndrome is a rare inborn heart condition in which delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes . These episodes may lead to palpitations, fainting and sudden death due to ventricular fibrillation...
type 3 (LQT3), Brugada syndrome
Brugada syndrome
The Brugada syndrome is a genetic disease that is characterised by abnormal electrocardiogram findings and an increased risk of sudden cardiac death. It is named by the Spanish cardiologists Pedro Brugada and Josep Brugada...
, primary cardiac conduction disease and idiopathic ventricular fibrillation
Ventricular fibrillation
Ventricular fibrillation is a condition in which there is uncoordinated contraction of the cardiac muscle of the ventricles in the heart, making them quiver rather than contract properly. Ventricular fibrillation is a medical emergency and most commonly identified arrythmia in cardiac arrest...
.
Interactions
Nav1.5 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with Syntrophin, alpha 1.
Nav1.5 interacts with ankyrin-G through a nine-amino acid ankyrin-G binding sequence.