SLC6A9
Encyclopedia
Sodium- and chloride-dependent glycine transporter 1 is a protein
that in humans is encoded by the SLC6A9 gene
.
concentration by blockade of GlyT1 has been hypothesized to potentiate NMDA receptor
function in vivo and to represent a rational approach for the treatment of schizophrenia and cognitive disorders.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SLC6A9 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Selective inhibitors
Elevation of extracellular synaptic glycineGlycine
Glycine is an organic compound with the formula NH2CH2COOH. Having a hydrogen substituent as its 'side chain', glycine is the smallest of the 20 amino acids commonly found in proteins. Its codons are GGU, GGC, GGA, GGG cf. the genetic code.Glycine is a colourless, sweet-tasting crystalline solid...
concentration by blockade of GlyT1 has been hypothesized to potentiate NMDA receptor
NMDA receptor
The NMDA receptor , a glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function....
function in vivo and to represent a rational approach for the treatment of schizophrenia and cognitive disorders.
- RG1678 which has entered phase II trials for the treatment of schizophrenia
- Org 25935Org 25935Org 25935 is a synthetic drug developed by Organon International, which acts as a selective inhibitor of the glycine transporter GlyT-1. In animal tests it reduces alcohol consumption and has analgesic and anticonvulsant effects, but it has mainly been studied for its antipsychotic properties, and...