SNRP70
Encyclopedia
snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein
that in humans is encoded by the SNRNP70 gene
. snRNP70 is a small nuclear ribonucleoprotein
that associates with U1 spliceosomal RNA
, forming part of the spliceosome
.
with ASF/SF2
, SRPK1
, and ZRANB2
.
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SNRNP70 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. snRNP70 is a small nuclear ribonucleoprotein
SnRNP
snRNPs , or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs...
that associates with U1 spliceosomal RNA
U1 spliceosomal RNA
U1 spliceosomal RNA is the small nuclear RNA component of U1 snRNP , an RNA-protein complex that combines with other snRNPs, unmodified pre-mRNA, and various other proteins to assemble a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs...
, forming part of the spliceosome
Spliceosome
A spliceosome is a complex of snRNA and protein subunits that removes introns from a transcribed pre-mRNA segment. This process is generally referred to as splicing.-Composition:...
.
Interactions
snRNP70 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with ASF/SF2
ASF/SF2
ASF/SF2 also known as splicing factor, arginine/serine-rich 1 or SFRS1, is a protein which in humans is encoded by the SFRS1 gene. ASF/SF2 is an essential sequence specific splicing factor involved in pre-mRNA splicing. SFRS1 is the gene that codes for ASF/SF2 and is found on chromosome 17...
, SRPK1
SRPK1
Serine/threonine-protein kinase SRPK1 is an enzyme that in humans is encoded by the SRPK1 gene.-Interactions:SRPK1 has been shown to interact with SNRP70 and ASF/SF2.-Further reading:...
, and ZRANB2
ZRANB2
Zinc finger Ran-binding domain-containing protein 2 is a protein that in humans is encoded by the ZRANB2 gene.-Interactions:ZRANB2 has been shown to interact with U2 small nuclear RNA auxiliary factor 1 and SNRP70.-Further reading:...
.
Role in autoimmunity
Antibodies towards snRNP70 are associated with mixed connective tissue diseaseMixed connective tissue disease
In medicine, mixed connective tissue disease , commonly abbreviated as MCTD, is an autoimmune disease, in which the body's defense system attacks itself. It was characterized in 1972....
.