SPI1
Encyclopedia
Transcription factor PU.1 is a protein
that in humans is encoded by the SPI1 gene
.
with NONO
, GATA2
, FUS
and IRF4
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the SPI1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Interactions
SPI1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with NONO
NONO
Non-POU domain-containing octamer-binding protein is a protein that in humans is encoded by the NONO gene.-Interactions:NONO has been shown to interact with SFPQ, SPI1 and Androgen receptor.-Further reading:...
, GATA2
GATA2
GATA binding protein 2, also known as GATA2, is a human gene. The protein encoded by this gene is a transcription factor.The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells...
, FUS
FUS
RNA-binding protein FUS is a protein that in humans is encoded by the FUS gene.- Function :The N-terminal end of FUS appears to be involved in transcriptional activation, while the C-terminal end is involved in protein and RNA binding...
and IRF4
IRF4
Interferon regulatory factor 4 is a protein that in humans is encoded by the IRF4 gene, also known as MUM1. In melanocytic cells the IRF4 gene may be regulated by MITF.-Interactions:IRF4 has been shown to interact with STAT6, NFATC2, BCL6 and SPI1....
.
See also
- Invasion gene associated RNA (InvR)Invasion gene associated RNA (InvR)Invasion gene associated RNA is a small non-coding RNA involved in regulating one of the major outer cell membrane porin proteins in Salmonella species....
, a ncRNA located in the SPI-1 region - Spi-1 (PU.1) 5' UTR regulatory elementSpi-1 (PU.1) 5' UTR regulatory elementThe Spi-1 5' UTR regulatory element is an RNA element found in the 5' UTR of Spi-1 mRNA which is able to inhibit the translation Spi-1 transcripts by 8-fold. Spi-1 regulates myeloid gene expression during haemopoietic development. Mutations in this regulatory region of the 5' UTR can lead to...