Santa Fe is an unincorporated community

Unincorporated area

In law, an unincorporated area is a region of land that is not a part of any municipality.To "incorporate" in this context means to form a municipal corporation, a city, town, or village with its own government. An unincorporated community is usually not subject to or taxed by a municipal government...

 in southeastern Monroe County, Missouri

Missouri

Missouri is a US state located in the Midwestern United States, bordered by Iowa, Illinois, Kentucky, Tennessee, Arkansas, Oklahoma, Kansas and Nebraska. With a 2010 population of 5,988,927, Missouri is the 18th most populous state in the nation and the fifth most populous in the Midwest. It...

, United States

United States

The United States of America is a federal constitutional republic comprising fifty states and a federal district...

. It is located about twenty-five miles north of Mexico, Missouri

Mexico, Missouri

Mexico is a city in Audrain County, Missouri, United States. The population was 11,543 at the 2010 census. It is the county seat of Audrain County. The Mexico Micropolitan Statistical Area consists of Audrain County...

 near the southern edge of Mark Twain Lake

Mark Twain Lake

Mark Twain Lake is located in Ralls County, Missouri and Monroe County, Missouri. It was created by the Clarence Cannon Dam impounding the Salt River and is located about twenty miles southwest of Hannibal. It was named for Missouri author Mark Twain and part of the area around it is Mark Twain...

. The Clemens family (of which was Samuel Clemens, aka "Mark Twain

Mark Twain

Samuel Langhorne Clemens , better known by his pen name Mark Twain, was an American author and humorist...

") owned several tracts of land in the area. It was settled in 1837 and named for Santa Fe, New Mexico

Santa Fe, New Mexico

Santa Fe is the capital of the U.S. state of New Mexico. It is the fourth-largest city in the state and is the seat of . Santa Fe had a population of 67,947 in the 2010 census...

. It was previously incorporated, but was disincorporated in 1950.