Schumm test
Encyclopedia
The Schumm test is a blood test http://www.pathology.co.za/RCPA/schumms_.htm that uses spectroscopy
to determine significant levels of methemalbumin
in the blood
. A positive result could indicate intravascular hemolysis
. The Schumm test was named for Otto Schumm, a German chemist who lived in the early 20th century.http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/eight/000107284.htm
A positive test result occurs when the haptoglobin
binding capacity of the blood is saturated, leading to heme released from cell free hemoglobin
to bind to albumin
.
Spectroscopy
Spectroscopy is the study of the interaction between matter and radiated energy. Historically, spectroscopy originated through the study of visible light dispersed according to its wavelength, e.g., by a prism. Later the concept was expanded greatly to comprise any interaction with radiative...
to determine significant levels of methemalbumin
Methemalbumin
Methemalbumin is an albumin complex consisting of albumin and heme.This complex gives brown color to plasma and occurs in hemolytic and hemorrhagic disorders.Its presence in plasma is used to differentiate between hemorrhagic and edematous pancreatitis....
in the blood
Blood
Blood is a specialized bodily fluid in animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells....
. A positive result could indicate intravascular hemolysis
Hemolysis
Hemolysis —from the Greek meaning "blood" and meaning a "loosing", "setting free" or "releasing"—is the rupturing of erythrocytes and the release of their contents into surrounding fluid...
. The Schumm test was named for Otto Schumm, a German chemist who lived in the early 20th century.http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/eight/000107284.htm
A positive test result occurs when the haptoglobin
Haptoglobin
Haptoglobin is a protein that in humans is encoded by the HP gene. In blood plasma, haptoglobin binds free hemoglobin released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system...
binding capacity of the blood is saturated, leading to heme released from cell free hemoglobin
Hemoglobin
Hemoglobin is the iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates, with the exception of the fish family Channichthyidae, as well as the tissues of some invertebrates...
to bind to albumin
Human serum albumin
Human serum albumin is the most abundant protein in human blood plasma. It is produced in the liver. Albumin constitutes about half of the blood serum protein...
.