Seronegative arthritis
Encyclopedia
A seronegative arthritis is an arthritis
that is distinguished from rheumatoid arthritis
due the absence of rheumatoid factor
(Rf-factor).
Arthritis
Arthritis is a form of joint disorder that involves inflammation of one or more joints....
that is distinguished from rheumatoid arthritis
Rheumatoid arthritis
Rheumatoid arthritis is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks synovial joints. The process produces an inflammatory response of the synovium secondary to hyperplasia of synovial cells, excess synovial fluid, and the development...
due the absence of rheumatoid factor
Rheumatoid factor
Rheumatoid factor is an autoantibody most relevant in rheumatoid arthritis. It is defined as an antibody against the Fc portion of IgG. RF and IgG join to form immune complexes that contribute to the disease process...
(Rf-factor).
Contrasting with rheumatoid arthritis
The seronegative arthritis family is differentiated from rheumatoid arthitis in many ways. Namely, rheumatoid arthritis is prevalent in the female population, whereas seronegative arthritis is more frequently seen in males.Types of seronegative arthritis
The following are types of seronegative arthritis that can be describes as Rf-factor negative:- Psoriatic arthritisPsoriatic arthritisPsoriatic arthritis is a type of inflammatory arthritis that, according to the National Psoriasis Foundation, will develop in up to 30 percent of people who have the chronic skin condition psoriasis...
- Reactive arthritisReactive arthritisReactive arthritis , is classified as an autoimmune condition that develops in response to an infection in another part of the body. Coming into contact with bacteria and developing an infection can trigger the disease. Reiter's syndrome has symptoms similar to various other conditions collectively...
aka Reiter's syndrome - Enteropathic arthritis
- Ankylosing spondylitisAnkylosing spondylitisAnkylosing spondylitis , previously known as Bekhterev's disease, Bekhterev syndrome, and Marie-Strümpell disease is a chronic inflammatory disease of the axial skeleton with variable involvement of peripheral joints and nonarticular structures...
- Undifferentiated seronegative arthritis
Treatment
The following are adequate treatments for seronegative arthritis:- NSAIDS (such as: meloxicamMeloxicamMeloxicam is a nonsteroidal anti-inflammatory drug with analgesic and fever reducer effects. It is a derivative of oxicam, closely related to piroxicam, and falls in the enolic acid group of NSAIDs...
) - DMARDS (such as: methotrexateMethotrexateMethotrexate , abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug. It is used in treatment of cancer, autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate...
)