Shire Pharmaceuticals Group
Encyclopedia
Shire Plc is a Jersey
-registered, Irish
-headquartered manufacturer of pharmaceuticals. Originating in and with a large operational base in the United Kingdom, its brands and products include Adderall XR, Carbatrol, Fosrenol, and the recently released Vyvanse.
Shire has its primary listing on the London Stock Exchange
and is a constituent of the FTSE 100 Index
. It has a secondary listing on NASDAQ
.
, Dr James Murray, Dennis Stephens, Peter Moriarty, and Geoff Hall in 1986. It was first listed on the London Stock Exchange
in 1996.
Shire has made a number of acquisitions over its history. These include:
The company focuses its drug research and development on the relatively common mental abnormality Attention Deficit Hyperactivity Disorder (ADHD), as is made evident by the fact that three of its currently leading medications (Adderall/Adderall XR, Daytrana, and the newly developed Vyvanse), are intended for that disorder. However the Company also works on gastrointestinal (GI) treatments, human genetic
therapies (HGT) and renal diseases.
{|{| class="wikitable" border="1"
|-
! style="width:200px;"|Name
! style="width:25px;"| Annual revenue
! style="width:300px;"|Indication
! Licensee
|-
|3TC (Lamivudine)
|$140.2M
|HIV
|GlaxoSmithKline
|-
|Zeffix (Lamivudine)
|$40.3M
|Chronic hepatitis B
|GlaxoSmithKline
|}
, Hampshire, England. Other major offices are located in the United States in Wayne
, Pennsylvania and Cambridge
, Massachusetts. In addition, Shire owns a manufacturing site in Lexington, Massachusetts
and Owings Mills
, Maryland.
in the treatment of royalties on patents, the company moved its tax domicile to Dublin, Ireland. Effected through the creation of a new holding company in St Helier, Jersey
in the Channel Islands
, it will pay reduced tax on global earnings, where royalties on patents lodged in Ireland are tax free.
and Michael Cola is the President of Specialty Pharmaceuticals.
Jersey
Jersey, officially the Bailiwick of Jersey is a British Crown Dependency off the coast of Normandy, France. As well as the island of Jersey itself, the bailiwick includes two groups of small islands that are no longer permanently inhabited, the Minquiers and Écréhous, and the Pierres de Lecq and...
-registered, Irish
Ireland
Ireland is an island to the northwest of continental Europe. It is the third-largest island in Europe and the twentieth-largest island on Earth...
-headquartered manufacturer of pharmaceuticals. Originating in and with a large operational base in the United Kingdom, its brands and products include Adderall XR, Carbatrol, Fosrenol, and the recently released Vyvanse.
Shire has its primary listing on the London Stock Exchange
London Stock Exchange
The London Stock Exchange is a stock exchange located in the City of London within the United Kingdom. , the Exchange had a market capitalisation of US$3.7495 trillion, making it the fourth-largest stock exchange in the world by this measurement...
and is a constituent of the FTSE 100 Index
FTSE 100 Index
The FTSE 100 Index, also called FTSE 100, FTSE, or, informally, the footsie , is a share index of the 100 most highly capitalised UK companies listed on the London Stock Exchange....
. It has a secondary listing on NASDAQ
NASDAQ
The NASDAQ Stock Market, also known as the NASDAQ, is an American stock exchange. "NASDAQ" originally stood for "National Association of Securities Dealers Automated Quotations". It is the second-largest stock exchange by market capitalization in the world, after the New York Stock Exchange. As of...
.
History
Shire was founded by Harry StratfordHarry Stratford
Harry Thomas Stratford OBE is the founder of Shire plc, one of the United Kingdom's largest pharmaceutical businesses.-Career:Educated at the University of London, Harry Stratford founded Shire Pharmaceticals in 1986 and remained its Chief Executive until 1994.In 1995 he founded ProStakan, another...
, Dr James Murray, Dennis Stephens, Peter Moriarty, and Geoff Hall in 1986. It was first listed on the London Stock Exchange
London Stock Exchange
The London Stock Exchange is a stock exchange located in the City of London within the United Kingdom. , the Exchange had a market capitalisation of US$3.7495 trillion, making it the fourth-largest stock exchange in the world by this measurement...
in 1996.
Shire has made a number of acquisitions over its history. These include:
- Richwood Pharmaceutical Company in 1995, which formed Shire-Richwood, Inc.
- Pharmavene in 1997
- Biochem Canada in 2001
- Transkaryotic Therapeutics (now Shire Human Genetic Therapies) in 2005
- New River Pharmaceuticals Inc, owners of Vyvanse, for $2.3bn in 2007.
- Movetis, a Belgian company focusing on gastrointestinal products, in 2010
- Advanced BioHealing, a regenerative medicine company, in 2011
Operations
Shire seeks to develop and market pharmaceutical products for specialty physicians. The company's in-licensing, merger and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the US or Europe.The company focuses its drug research and development on the relatively common mental abnormality Attention Deficit Hyperactivity Disorder (ADHD), as is made evident by the fact that three of its currently leading medications (Adderall/Adderall XR, Daytrana, and the newly developed Vyvanse), are intended for that disorder. However the Company also works on gastrointestinal (GI) treatments, human genetic
Genetics
Genetics , a discipline of biology, is the science of genes, heredity, and variation in living organisms....
therapies (HGT) and renal diseases.
Products
| Name | Annual revenue | Indication |
|---|---|---|
| Adderall XR | $1.1B | Attention Deficit Hyperactivity Disorder (ADHD) |
| Vyvanse | $318.9M | Attention Deficit Hyperactivity Disorder (ADHD) |
| Elaprase | $305.1M | Hunter syndrome Hunter syndrome Hunter syndrome, or mucopolysaccharidosis Type II, is a lysosomal storage disease caused by a deficient enzyme, iduronate-2-sulfatase . The syndrome is named after physician Charles A. Hunter , who first described it in 1917... (lysosomal storage disorder) |
| Pentasa | $185.5M | Gastrointestinal (Ulcerative colitis Ulcerative colitis Ulcerative colitis is a form of inflammatory bowel disease . Ulcerative colitis is a form of colitis, a disease of the colon , that includes characteristic ulcers, or open sores. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset... ) |
| Replagal | $176.1M | Fabry disease (lysosomal storage disorder) |
| Fosrenol | $155.4M | Renal disease |
| Lialda/Mezavant | $140.4M | Gastrointestinal (Ulcerative colitis Ulcerative colitis Ulcerative colitis is a form of inflammatory bowel disease . Ulcerative colitis is a form of colitis, a disease of the colon , that includes characteristic ulcers, or open sores. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset... ) |
| Daytrana Daytrana Daytrana is a medicinal patch marketed by Shire Pharmaceuticals and developed under contract by Noven Pharmaceuticals that was approved in June 2007. In the literature, Daytrana is most commonly referred to as Methylphenidate Transdermal System .Daytrana is approved by the U.S... |
$78.7M | Attention Deficit Hyperactivity Disorder (ADHD) |
| Xagrid (sold as Agrylin in the U.S.) | $78.7M | Essential thrombocytosis Essential thrombocytosis Essential thrombocythemia is a rare chronic blood disorder characterized by the overproduction of platelets by megakaryocytes in the bone marrow in the absence of an alternative cause. In some cases this disorder may be progressive, and rarely may evolve into acute myeloid leukemia or myelofibrosis... |
| Carbatrol | $75.9M | Epilepsy Epilepsy Epilepsy is a common chronic neurological disorder characterized by seizures. These seizures are transient signs and/or symptoms of abnormal, excessive or hypersynchronous neuronal activity in the brain.About 50 million people worldwide have epilepsy, and nearly two out of every three new cases... |
| Calcichew (UK) | $52.8M | Calcium supplements |
| Reminyl/Reminyl XL | $34.4M | Alzheimer's disease Alzheimer's disease Alzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death... |
| Firazyr | $0.5M | Cardiovascular (Hereditary angioedema Hereditary angioedema Hereditary angioedema presents in the second to fourth decade, and is characterized by local swelling in subcutaneous tissues.... ) |
| Intuniv | Attention Deficit Hyperactivity Disorder (ADHD) |
Royalty income
{|{| class="wikitable" border="1"
|-
! style="width:200px;"|Name
! style="width:25px;"| Annual revenue
! style="width:300px;"|Indication
! Licensee
|-
|3TC (Lamivudine)
Lamivudine
Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor .It is marketed by GlaxoSmithKline with the brand names Zeffix, Heptovir, Epivir, and Epivir-HBV.Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV...
|$140.2M
|HIV
|GlaxoSmithKline
GlaxoSmithKline
GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...
|-
|Zeffix (Lamivudine)
Lamivudine
Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor .It is marketed by GlaxoSmithKline with the brand names Zeffix, Heptovir, Epivir, and Epivir-HBV.Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV...
|$40.3M
|Chronic hepatitis B
|GlaxoSmithKline
GlaxoSmithKline
GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...
|}
Locations
The original corporate head quarters and still major operation base are located in BasingstokeBasingstoke
Basingstoke is a town in northeast Hampshire, in south central England. It lies across a valley at the source of the River Loddon. It is southwest of London, northeast of Southampton, southwest of Reading and northeast of the county town, Winchester. In 2008 it had an estimated population of...
, Hampshire, England. Other major offices are located in the United States in Wayne
Wayne, Pennsylvania
Wayne is an unincorporated community located on the Main Line, centered in Delaware County, Pennsylvania, United States. While the center of Wayne is in Radnor Township, Wayne extends into both Tredyffrin Township in Chester County and Upper Merion Township in Montgomery County...
, Pennsylvania and Cambridge
Cambridge, Massachusetts
Cambridge is a city in Middlesex County, Massachusetts, United States, in the Greater Boston area. It was named in honor of the University of Cambridge in England, an important center of the Puritan theology embraced by the town's founders. Cambridge is home to two of the world's most prominent...
, Massachusetts. In addition, Shire owns a manufacturing site in Lexington, Massachusetts
Lexington, Massachusetts
Lexington is a town in Middlesex County, Massachusetts, United States. The population was 31,399 at the 2010 census. This town is famous for being the site of the first shot of the American Revolution, in the Battle of Lexington on April 19, 1775.- History :...
and Owings Mills
Owings Mills, Maryland
Owings Mills is an unincorporated community and a census-designated place in Baltimore County, Maryland, United States. It is a suburb of Baltimore. The population was 20,193 at the 2000 census. Owings Mills is home to the northern terminus for the Baltimore Metro Subway and to Owings Mills Mall....
, Maryland.
Tax Avoidance
In 2008, in reaction to new taxation measures announced by the Labour PartyLabour Party (UK)
The Labour Party is a centre-left democratic socialist party in the United Kingdom. It surpassed the Liberal Party in general elections during the early 1920s, forming minority governments under Ramsay MacDonald in 1924 and 1929-1931. The party was in a wartime coalition from 1940 to 1945, after...
in the treatment of royalties on patents, the company moved its tax domicile to Dublin, Ireland. Effected through the creation of a new holding company in St Helier, Jersey
Jersey
Jersey, officially the Bailiwick of Jersey is a British Crown Dependency off the coast of Normandy, France. As well as the island of Jersey itself, the bailiwick includes two groups of small islands that are no longer permanently inhabited, the Minquiers and Écréhous, and the Pierres de Lecq and...
in the Channel Islands
Channel Islands
The Channel Islands are an archipelago of British Crown Dependencies in the English Channel, off the French coast of Normandy. They include two separate bailiwicks: the Bailiwick of Guernsey and the Bailiwick of Jersey...
, it will pay reduced tax on global earnings, where royalties on patents lodged in Ireland are tax free.
Corporate leadership
The non-executive Board Chairman is Matthew Emmens. Angus Russell is the Chief Executive Officer. The President of the Human Genetic Therapies division is Sylvie GregoireSylvie Gregoire
Dr. Sylvie Louise Grégoire, PharmD is a Massachusetts biotechnology and pharmaceutical company executive. She is currently the President of the Human Genetics division at Shire plc. Gregoire has a doctorate in Pharmacy and Pharmacology...
and Michael Cola is the President of Specialty Pharmaceuticals.