In the 1526 siege of Kamakura, Satomi Sanetaka led forces of the Uesugi clan

Uesugi clan

The was a Japanese samurai clan, descended from the Fujiwara clan and particularly notable for their power in the Muromachi and Sengoku periods ....

 against the Hōjō

Late Hojo clan

The ' was one of the most powerful warrior clans in Japan in the Sengoku period and held domains primarily in the Kantō region.The clan is traditionally reckoned to be started by Ise Shinkurō, who came from a branch of the prestigious Ise clan, a family in the direct employment of the Ashikaga...

, who had taken Edo

Edo

, also romanized as Yedo or Yeddo, is the former name of the Japanese capital Tokyo, and was the seat of power for the Tokugawa shogunate which ruled Japan from 1603 to 1868...

 from the Uesugi two years earlier. The city was defended by a number of retainers of Hōjō Ujitsuna

Hojo Ujitsuna

was the son of Hōjō Sōun, founder of the Go-Hōjō clan. He continued his father's quest to gain control of the Kantō ....

, including members of the Itō and Ogasawara families.

The Uesugi forces burned much of the city to the ground, including Tsurugaoka Hachiman-gū. This was a terrible psychological loss for the Hōjō, since the earlier Hōjō clan

Hojo clan

See the late Hōjō clan for the Hōjō clan of the Sengoku Period.The in the history of Japan was a family who controlled the hereditary title of shikken of the Kamakura Shogunate. In practice, the family had actual governmental power, many times dictatorial, rather than Kamakura shoguns, or the...

, from which they took their name, had suffered their final defeat

Siege of Kamakura (1333)

The 1333 siege of Kamakura was a battle of the Genkō War, and marked the end of the power of the Hōjō clan, which had dominated the regency of the Kamakura shogunate for over a century...

 at the same location in 1333.