The Sign of Hertoghe or Queen Anne's sign is a thinning or loss of the outer third of the eyebrows, and is a sign of hypothyroidism

Hypothyroidism

Hypothyroidism is a condition in which the thyroid gland does not make enough thyroid hormone.Iodine deficiency is the most common cause of hypothyroidism worldwide but it can be caused by other causes such as several conditions of the thyroid gland or, less commonly, the pituitary gland or...

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The sign is named for Eugene Hertoghe of Antwerp, a pioneer in thyroid function research.

Queen Anne's sign

The association with Anne of Denmark

Anne of Denmark

Anne of Denmark was queen consort of Scotland, England, and Ireland as the wife of King James VI and I.The second daughter of King Frederick II of Denmark, Anne married James in 1589 at the age of fourteen and bore him three children who survived infancy, including the future Charles I...

 is based on portraiture, and history does not suggest that she suffered an underactive thyroid. The eponym is disputed by some, though it has been suggested that Anne of France

Anne of France

Anne of France was the eldest daughter of Louis XI of France and his second wife, Charlotte of Savoy. Anne was the sister of King Charles VIII of France, for whom she acted as regent during his minority; and of Joan of France, who was briefly queen consort to Louis XII...

, Anne of Brittany

Anne of Brittany

Anne, Duchess of Brittany , also known as Anna of Brittany , was a Breton ruler, who was to become queen to two successive French kings. She was born in Nantes, Brittany, and was the daughter of Francis II, Duke of Brittany and Margaret of Foix. Her maternal grandparents were Queen Eleanor of...

, Anne of Austria

Anne of Austria

Anne of Austria was Queen consort of France and Navarre, regent for her son, Louis XIV of France, and a Spanish Infanta by birth...

, Anne Boleyn

Anne Boleyn

Anne Boleyn ;c.1501/1507 – 19 May 1536) was Queen of England from 1533 to 1536 as the second wife of Henry VIII of England and Marquess of Pembroke in her own right. Henry's marriage to Anne, and her subsequent execution, made her a key figure in the political and religious upheaval that was the...

 and Anne of Cleves

Anne of Cleves

Anne of Cleves was a German noblewoman and the fourth wife of Henry VIII of England and as such she was Queen of England from 6 January 1540 to 9 July 1540. The marriage was never consummated, and she was not crowned queen consort...

may all be eliminated as candidates.