Signet ring cell carcinoma
Encyclopedia
Signet ring cell carcinoma is an epithelial
malignancy characterized by the histologic
appearance of signet ring cell
s.
It is a form of adenocarcinoma
.
displaces the nucleus to the periphery.
Epithelium
Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. Epithelial tissues line the cavities and surfaces of structures throughout the body, and also form many glands. Functions of epithelial cells include secretion, selective...
malignancy characterized by the histologic
Histology
Histology is the study of the microscopic anatomy of cells and tissues of plants and animals. It is performed by examining cells and tissues commonly by sectioning and staining; followed by examination under a light microscope or electron microscope...
appearance of signet ring cell
Signet ring cell
In histology, a signet ring cell is a malignant cell type seen predominantly in carcinomas.Signet ring cells are most frequently associated with stomach cancer, but can arise from any number of tissues including the prostate, bladder, gallbladder, breast, colon, ovarian stroma and...
s.
It is a form of adenocarcinoma
Adenocarcinoma
Adenocarcinoma is a cancer of an epithelium that originates in glandular tissue. Epithelial tissue includes, but is not limited to, the surface layer of skin, glands and a variety of other tissue that lines the cavities and organs of the body. Epithelium can be derived embryologically from...
.
Histologic appearance
Signet ring cells resemble signet rings because a large vacuole full of mucinMucin
Mucins are a family of high molecular weight, heavily glycosylated proteins produced by epithelial tissues in most metazoans. Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell...
displaces the nucleus to the periphery.