"Stay Fly" is the first single from rap group Three 6 Mafia

Three 6 Mafia

Three 6 Mafia are an Academy Award-winning, American rap group originating from Memphis, Tennessee. Formed in 1991 as Triple 6 Mafia, by DJ Paul, Juicy J, & Lord Infamous, the group at its most featured six members including; Crunchy Black, Gangsta Boo and Koopsta Knicca...

's 2005 album Most Known Unknown

Most Known Unknown

Most Known Unknown is the eighth full length studio album, as well as the second platinum album from Memphis rap group Three 6 Mafia. It was released in 2005, and is the follow-up to the 2003 album Da Unbreakables...

. The song peaked at #13 on the Billboard Hot 100

Billboard Hot 100

The Billboard Hot 100 is the United States music industry standard singles popularity chart issued weekly by Billboard magazine. Chart rankings are based on radio play and sales; the tracking-week for sales begins on Monday and ends on Sunday, while the radio play tracking-week runs from Wednesday...

 to become the group's biggest hit. The track (which samples "Tell Me Why Has Our Love Turned Cold" by Willie Hutch

Willie Hutch

Willie McKinley Hutchison, known professionally as Willie Hutch was an American singer, songwriter as well as a record producer and recording artist for the Motown record label during the 1970s and 1980s....

) features Memphis rap group 8Ball & MJG

8Ball & MJG

8Ball & MJG is an American Rap and Crunk duo from Memphis, Tennessee. The two rappers met at in 1980.They first appeared on the rap scene with their 1992 underground album Listen To The Lyrics...

 and Young Buck

Young Buck

David Darnell Brown , also known as Young Buck, is an American Southern rapper. Buck is a former member of the New York City Hip-Hop group G-Unit, also a former artist of G-Unit Records as of Nov 26, 2011...

, then a member of G-Unit

G-Unit

G-Unit is an American hip hop group originating from New York City formed by 50 Cents. G-Unit emerged on the New York scene by independently releasing several mix tapes...

.

The song's original title ("Stay High", a reference to drugs) was changed for radio airplay. The single helped propel Most Known Unknown to platinum status.

Music video

The video features an appearance from newly-recruited G-Unit

G-Unit

G-Unit is an American hip hop group originating from New York City formed by 50 Cents. G-Unit emerged on the New York scene by independently releasing several mix tapes...

 member Spider Loc

Spider Loc

Curtis Norvell Williams, more commonly known as Spider Loc is an American rapper signed to G-Unit Records.Loc is also the CEO of G-Unit West.-Biography:...

. Remixes featured Southern rappers such as Trick Daddy

Trick Daddy

Maurice Young , better known by his stage name Trick Daddy, is a certified platinum American rapper and producer from Miami, Florida.-Music career:...

, Slim Thug

Slim Thug

Stayve Jerome Thomas , better known as Slim Thug, Boss Hogg or Thug Boss, is an American rapper. He gained mainstream attention for his contribution to the popular single from rapper Mike Jones, "Still Tippin'"....

, Three 6 Mafia affiliate Project Pat

Project Pat

Patrick Houston, better known as Project Pat is an American rapper originating from Memphis, Tennessee. He is the older brother of Juicy J, co-founder of the Three 6 Mafia....

 and Lil' Flip

Lil' Flip

Wesley Eric Weston, Jr. , better known by his stage name Lil' Flip, is a American multi-platinum hiphop artist best known for his singles Sunshine, "Game Over" and Rollin on 20's from the 2 Fast 2 Furious Soundtrack....

. The "Bay Area Remix" features E-40

E-40

Earl Stevens , better known by his stage name E-40, is an American rapper, entrepreneur, and investor from Vallejo, California. He is also part of the rap group The Click and the founder of Sick Wid It Records. His solo debut album, Federal, was released in November 1992, after The Click's debut...

. The screwed and chopped version (done by Michael 5000 Watts) features part of the instrumental of "Pussy Got Ya Hooked".