Stepholidine
Encyclopedia
-Stepholidine is a naturally occurring chemical compound found in the herb Stephania intermedia
. Stepholidine is a dual D2 receptor
antagonist
and D1 receptor
agonist
, and has shown antipsychotic
activity in animal studies.
Stephania
Stephania is a genus of flowering plants in the family Menispermaceae, native to eastern and southern Asia and Australasia. They are herbaceous perennial vines growing to around four metres tall, with a large, woody caudex. The leaves are arranged spirally on the stem, and are peltate, with the...
. Stepholidine is a dual D2 receptor
Dopamine receptor D2
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.- Function :This gene encodes the D2 subtype of the dopamine receptor. This G protein-coupled receptor inhibits adenylyl cyclase activity...
antagonist
Dopamine antagonist
A dopamine antagonist is a drug which blocks dopamine receptors by receptor antagonism. There are five known types of dopamine receptors in the human body; they are found in the brain, peripheral nervous system, blood vessels, gastrointestinal tract and the kidney.-Uses and examples:* Used as...
and D1 receptor
Dopamine receptor D1
Dopamine receptor D1, also known as DRD1, is a protein that in humans is encoded by the DRD1 gene.- Function :This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein-coupled receptor stimulates...
agonist
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
, and has shown antipsychotic
Antipsychotic
An antipsychotic is a tranquilizing psychiatric medication primarily used to manage psychosis , particularly in schizophrenia and bipolar disorder. A first generation of antipsychotics, known as typical antipsychotics, was discovered in the 1950s...
activity in animal studies.
See also
- ApomorphineApomorphineApomorphine is a non-selective dopamine agonist which activates both D1-like and D2-like receptors, with some preference for the latter subtypes. It is historically a morphine decomposition product by boiling with concentrated acid, hence the -morphine suffix...
- BulbocapnineBulbocapnineBulbocapnine is an alkaloid found in Corydalis and Dicentra, herbs in the family Fumariaceae that can cause fatal poisoning in sheep and cattle...
- GlaucineGlaucineGlaucine is an alkaloid found in several different plant species such as Glaucium flavum, Glaucium oxylobum, Croton lechleri and Corydalis yanhusuo. It has bronchodilator and antiinflammatory effects, acting as a PDE4 inhibitor and calcium channel blocker, and is used medically as an antitussive in...
- NuciferineNuciferineNuciferine is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade. It induces catalepsy, it inhibits spontaneous motor activity, conditioned avoidance response, amphetamine toxicity and stereotypy...
- PukateinePukateinePukateine is an alkaloid found in the bark of the New Zealand tree Laurelia novae-zelandiae . An extract from pukatea is used in traditional Māori herbal medicine as an analgesic, and it is thought pukateine is the active component, as it is similar in both structure and activity to alkaloids such...
- TetrahydropalmatineTetrahydropalmatineTetrahydropalmatine is an alkaloid found in several different plant species, mainly in the Corydalis family, but also in other plants such as Stephania rotunda. These plants have traditional uses in Chinese herbal medicine...