Stratum spinosum
Encyclopedia
The stratum spinosum is a layer of the epidermis found between the stratum granulosum
Stratum granulosum
The stratum granulosum is a thin layer of cells in the epidermis. Keratinocytes migrating from the underlying stratum spinosum become known as granular cells in this layer...

 and stratum basale
Stratum germinativum
The stratum basale is the deepest layer of the five layers of the epidermis, which is the outer covering of skin in mammals. The stratum basale is a continuous layer of cells...

. This layer is also referred to as the "spinous" or "prickle-cell" layer. This appearance is due to desmosomal
Desmosome
A desmosome , also known as macula adherens , is a cell structure specialized for cell-to-cell adhesion...

 connections of adjacent cells. Keratinization begins in the stratum spinosum.
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