Sulfiram
Encyclopedia
Sulfiram or monosulfiram, trade name Tetmosol, is an ectoparasiticide
used in the treatment and prevention of scabies
. It is usually sold as a solution or medicated soap
, sometimes in combination with benzyl benzoate
.
Sulfiram is now rarely used, but, , is still available in Brazil, India, and South Africa (as monotherapy) and France (with benzyl benzoate).
tous rash
may occur. A single case of toxic epidermal necrolysis
was reported in 1968.
Sulfiram is structurally related to disulfiram
(Antabuse), and readily converts to disulfiram when exposed to light. Like disulfiram, it can produce an unpleasant reaction when consumed with alcohol.
Ectoparasiticide
An ectoparasiticide is an antiparasitic drug used in the treatment of ectoparasitic infestations.An example is lindane....
used in the treatment and prevention of scabies
Scabies
Scabies , known colloquially as the seven-year itch, is a contagious skin infection that occurs among humans and other animals. It is caused by a tiny and usually not directly visible parasite, the mite Sarcoptes scabiei, which burrows under the host's skin, causing intense allergic itching...
. It is usually sold as a solution or medicated soap
Soap
In chemistry, soap is a salt of a fatty acid.IUPAC. "" Compendium of Chemical Terminology, 2nd ed. . Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford . XML on-line corrected version: created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN...
, sometimes in combination with benzyl benzoate
Benzyl benzoate
Benzyl benzoate is the ester of benzyl alcohol and benzoic acid, with the formula C6H5CH2O2CC6H5. This easily prepared compound has a variety of uses.-Synthesis:This colorless liquid is formally the condensation product of benzoic acid and benzyl alcohol...
.
Sulfiram is now rarely used, but, , is still available in Brazil, India, and South Africa (as monotherapy) and France (with benzyl benzoate).
Adverse effects
Dizziness, headache, fatigue and erythemaErythema
Erythema is redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin. It occurs with any skin injury, infection, or inflammation...
tous rash
Drug eruption
In medicine, a drug eruption is an adverse drug reaction of the skin. Most drug-induced cutaneous reactions are mild and disappear when the offending drug is withdrawn. Drugs can also cause hair and nail changes, affect the mucous membranes, or cause itching without outward skin...
may occur. A single case of toxic epidermal necrolysis
Toxic epidermal necrolysis
Toxic epidermal necrolysis is a rare, life-threatening dermatological condition that is usually induced by a reaction to medications...
was reported in 1968.
Sulfiram is structurally related to disulfiram
Disulfiram
Disulfiram is a drug discovered in the 1920s and used to support the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Trade names for disulfiram in different countries are Antabuse and Antabus manufactured by Odyssey Pharmaceuticals...
(Antabuse), and readily converts to disulfiram when exposed to light. Like disulfiram, it can produce an unpleasant reaction when consumed with alcohol.
External links
- Tetmosol* soap – South African Electronic Package Insert