Sulfotransferase
Encyclopedia
Transferase
In biochemistry, a transferase is an enzyme that catalyzes the transfer of a functional group from one molecule to another . For example, an enzyme that catalyzed this reaction would be a transferase:In this example, A would be the donor, and B would be the acceptor...
enzymes that catalyze the transfer of a sulfate
Sulfate
In inorganic chemistry, a sulfate is a salt of sulfuric acid.-Chemical properties:...
group from a donor molecule to an acceptor alcohol or amine. The most common sulfate donor is 3'-phosphoadenosine-5'-phosphosulfate
3'-Phosphoadenosine-5'-phosphosulfate
3'-Phosphoadenosine-5'-phosphosulfate is a derivative of adenosine monophosphate that is phosphorylated at the 3' position and has a sulfate group attached to the 5' phosphate. This anion, abbreviated PAPS, serves as a coenzyme in sulfotransferase reactions...
(PAPS). The destination alcohol or amine may be part of a protein, lipid, carbohydrate or steroid.
Examples
The following are examples of sulfotransferases:- carbohydrate sulfotransferaseCarbohydrate sulfotransferaseCarbohydrate sulfotransferases are sulfotransferase enzymes that transfer sulfate to carbohydrate groups in glycoproteins and glycolipids. These include:...
: CHST1CHST1Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.-Further reading:...
, CHST2CHST2Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.-Further reading:...
, CHST3, CHST4CHST4Carbohydrate sulfotransferase 4 is an enzyme that in humans is encoded by the CHST4 gene.-Further reading:...
, CHST5CHST5Carbohydrate sulfotransferase 5 is an enzyme that in humans is encoded by the CHST5 gene.-Further reading:...
, CHST6CHST6Carbohydrate sulfotransferase 6 is an enzyme that in humans is encoded by the CHST6 gene.It codes for an enzyme necessary for the production of keratan sulfate. Mutations in the gene lead to macular corneal dystrophy.-Further reading:...
, CHST7CHST7Carbohydrate sulfotransferase 7 is an enzyme that in humans is encoded by the CHST7 gene.-Further reading:...
, CHST8, CHST9, CHST10CHST10Carbohydrate sulfotransferase 10 is an enzyme that in humans is encoded by the CHST10 gene.-Further reading:...
, CHST11CHST11Carbohydrate sulfotransferase 11 is an enzyme that in humans is encoded by the CHST11 gene.-Further reading:...
, CHST12CHST12Carbohydrate sulfotransferase 12 is an enzyme that in humans is encoded by the CHST12 gene.-Further reading:...
, CHST13, CHST14CHST14Carbohydrate sulfotransferase 14 is an enzyme that in humans is encoded by the CHST14 gene.-Further reading:... - galactose-3-O-sulfotransferaseGalactose-3-O-sulfotransferaseGalactose-3-O-sulfotransferases is a family of several mammalian galactose-3-O-sulfotransferase proteins. Gal-3-O-sulfotransferase is thought to play a critical role in 3'-sulfation of N-acetyllactosamine in both O- and N-glycans....
: GAL3ST1GAL3ST1Galactosylceramide sulfotransferase is an enzyme that in humans is encoded by the GAL3ST1 gene.-Further reading:...
, GAL3ST2GAL3ST2Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene.-Further reading:...
, GAL3ST3GAL3ST3Galactose-3-O-sulfotransferase 3 is an enzyme that in humans is encoded by the GAL3ST3 gene.-Further reading:...
, GAL3ST4GAL3ST4Galactose-3-O-sulfotransferase 4 is an enzyme that in humans is encoded by the GAL3ST4 gene.-Further reading:... - heparan sulfate 2-O-sulfotransferaseHeparan sulfate 2-O-sulfotransferaseHeparan sulfate 2-O-sulfotransferase is a sulfotransferase enzyme. Heparan sulfate is a long unbranched polysaccharide found covalently attached to various proteins at the cell surface and in the extracellular matrix, where it acts as a co-receptor for a number of growth factors, morphogens, and...
: HS2ST1HS2ST1Heparan sulfate 2-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS2ST1 gene.-Further reading:...
, - heparan sulfate 3-O-sulfotransferase: HS3ST1HS3ST1Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.-Further reading:...
, HS3ST2HS3ST2Heparan sulfate glucosamine 3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the HS3ST2 gene.-Further reading:...
, HS3ST3A1HS3ST3A1Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene.-Further reading:...
, HS3ST3A2, HS3ST3B1HS3ST3B1Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene.-Further reading:...
, HS3ST3B2, HS3ST4, HS3ST5, HS3ST6 - heparan sulfate 6-O-sulfotransferaseHeparan sulfate 6-O-sulfotransferaseHeparan sulfate 6-sulfotransferases catalyses the transfer of sulfate from adenosine 3'-phosphate, 5'-phosphosulfate to the 6th position of the N-sulfoglucosamine residue in heparan sulfate.-References:...
: HS6ST1, HS6ST2, HS6ST3 - N-deacetylase/N-sulfotransferase: NDST1NDST1Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 is an enzyme. In humans, it is encoded by the NDST1 gene.-Further reading:...
, NDST2NDST2Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 is an enzyme that in humans is encoded by the NDST2 gene.-Further reading:...
, NDST3NDST3Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene.-Further reading:...
, NDST4 - tyrosylprotein sulfotransferaseTyrosylprotein sulfotransferaseTyrosylprotein sulfotransferase is an enzyme that catalyzes tyrosine sulfation.- Examples :Human genes that encode protein-tyrosine sulfotransferase enzymes include:...
: TPST1, TPST2 - uronyl-2-sulfotransferase: USTUSTUST is a three letter acronym that may refer to:* Equatorial Guinea Workers' Union* Hong Kong University of Science and Technology * Northeast Florida Regional Airport in St...
- Estrone sulfotransferaseEstrone sulfotransferaseIn enzymology, an estrone sulfotransferase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and estrone, whereas its two products are adenosine 3',5'-bisphosphate and estrone 3-sulfate....
- Chondroitin 4-sulfotransferaseChondroitin 4-sulfotransferaseIn enzymology, a chondroitin 4-sulfotransferase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and chondroitin, whereas its two products are adenosine 3',5'-bisphosphate and chondroitin 4'-sulfate.This enzyme belongs to the...
- other: SULT1A1SULT1A1Sulfotransferase 1A1 is an enzyme that in humans is encoded by the SULT1A1 gene.-Further reading:...
, SULT1A2SULT1A2Sulfotransferase 1A2 is an enzyme that in humans is encoded by the SULT1A2 gene.-Further reading:...
, SULT1A3SULT1A3Sulfotransferase 1A3/1A4 is an enzyme that in humans is encoded by the SULT1A3 gene.-Further reading:...
, SULT1A4, SULT1B1SULT1B1Sulfotransferase family cytosolic 1B member 1 is an enzyme that in humans is encoded by the SULT1B1 gene.-Further reading:...
, SULT1C2SULT1C2Sulfotransferase 1C2 is an enzyme that in humans is encoded by the SULT1C2 gene.-Further reading:...
, SULT1C3SULT1C3Sulfotransferase 1C3, also known as ST1C3, is an enzyme that in humans is encoded by the SULT1C3 gene.- Function :Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue...
, SULT1C4SULT1C4Sulfotransferase 1C4 is an enzyme that in humans is encoded by the SULT1C4 gene.-Further reading:...
, SULT1D1P, SULT1E1SULT1E1Estrogen sulfotransferase is an enzyme that in humans is encoded by the SULT1E1 gene.-Further reading:...
, SULT2A1SULT2A1Alcohol sulfotransferase is an enzyme that catalyzes the sulfate conjugation of primary and secondary alcohols including many hormones, neurotransmitters, drugs, and xenobiotic compounds.- Family members :...
, SULT2B1SULT2B1Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene.-Further reading:...
, SULT4A1SULT4A1Sulfotransferase 4A1 is an enzyme that in humans is encoded by the SULT4A1 gene.-Further reading:...
, SULT6B1
See also
- List of EC numbers %28EC 2%29#EC 2.8.2: Sulfotransferases
- Wikipedia:MeSH D08#MeSH D08.811.913.817 --- sulfur group transferases .28EC 2.8.29